Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Ccel_0097KEGG: cth:Cthe_2241 hypothetical protein. (193 aa)    
Predicted Functional Partners:
Ccel_0093
PFAM: FlgN family protein; KEGG: cth:Cthe_2245 hypothetical protein.
 
  
 0.920
Ccel_0096
TIGRFAM: flagellar hook-associated protein 3; PFAM: flagellin domain protein; KEGG: cth:Cthe_2242 flagellar hook-associated protein FlgL.
 
  
 0.854
fliW
Protein of unknown function DUF180; Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
 
  
 0.851
Ccel_0092
PFAM: Anti-sigma-28 factor FlgM family protein; KEGG: cth:Cthe_2246 anti-sigma-28 factor, FlgM.
 
  
 0.821
flgK
TIGRFAM: flagellar hook-associated protein FlgK; PFAM: flagellar basal body rod protein; protein of unknown function DUF1078 domain protein; KEGG: cth:Cthe_2243 flagellar hook-associated protein FlgK.
 
  
 0.810
Ccel_0094
TIGRFAM: flagellar hook-associated protein FlgK; PFAM: von Willebrand factor type A; protein of unknown function DUF1078 domain protein; KEGG: cth:Cthe_2244 flagellar hook-associated protein FlgK.
 
  
 0.778
Ccel_0091
KEGG: cth:Cthe_2247 regulatory protein, MerR.
 
  
 0.771
csrA
Carbon storage regulator, CsrA; A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'- UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
  
    0.740
Ccel_0107
PFAM: FlgN family protein; KEGG: cth:Cthe_2216 hypothetical protein.
 
     0.685
Ccel_2076
KEGG: cth:Cthe_0889 putative transmembrane anti-sigma factor.
  
     0.683
Your Current Organism:
Ruminiclostridium cellulolyticum
NCBI taxonomy Id: 394503
Other names: Clostridium cellulolyticum H10, R. cellulolyticum H10, Ruminiclostridium cellulolyticum H10
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