Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
birAbiotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. (326 aa)    
Predicted Functional Partners:
Ccel_3189
PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: cpy:Cphy_2083 biotin synthase.
  
 
 0.963
coaX
Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family.
  
    0.943
Ccel_0800
PFAM: peptidase M22 glycoprotease; KEGG: cth:Cthe_1775 peptidase M22, glycoprotease.
 
    0.927
Ccel_1738
PFAM: carboxyl transferase; KEGG: cth:Cthe_0699 carboxyl transferase.
 
 
 0.921
tadA
CMP/dCMP deaminase zinc-binding; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family.
  
    0.916
Ccel_2295
PFAM: Polynucleotide adenylyltransferase region; metal-dependent phosphohydrolase HD sub domain; KEGG: cth:Cthe_1389 metal dependent phosphohydrolase.
 
  
 0.889
Ccel_3322
TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase; KEGG: cth:Cthe_0458 exodeoxyribonuclease III Xth.
  
    0.885
Ccel_0133
KEGG: cth:Cthe_2584 hypothetical protein.
       0.841
Ccel_1737
PFAM: biotin/lipoyl attachment domain-containing protein; KEGG: cth:Cthe_0700 biotin/lipoyl attachment protein.
 
  
 0.797
Ccel_3231
PFAM: BioY protein; KEGG: cbe:Cbei_1913 BioY protein.
 
   
 0.795
Your Current Organism:
Ruminiclostridium cellulolyticum
NCBI taxonomy Id: 394503
Other names: Clostridium cellulolyticum H10, R. cellulolyticum H10, Ruminiclostridium cellulolyticum H10
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