Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Ccel_0176PFAM: peptidase U32; KEGG: cth:Cthe_2086 peptidase U32. (835 aa)    
Predicted Functional Partners:
Ccel_2304
PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; 4Fe-4S ferredoxin, iron-sulphur binding, conserved site; KEGG: aoe:Clos_0989 NADH dehydrogenase (quinone).
  
   0.784
Ccel_0175
PFAM: metalloenzyme domain protein; KEGG: cth:Cthe_2087 metalloenzyme.
       0.724
Ccel_0177
Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
  
    0.679
Ccel_1473
PFAM: O-methyltransferase family 3; Methyltransferase type 11; KEGG: cth:Cthe_1009 O-methyltransferase family protein.
  
  
 0.673
hflX
GTP-binding proten HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
       0.578
Ccel_3368
PFAM: NADH dehydrogenase (ubiquinone) 30 kDa subunit; KEGG: csc:Csac_1537 NADH dehydrogenase (ubiquinone), 30 kDa subunit.
   
   0.514
Ccel_0174
Protein of unknown function DUF710; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.
     
 0.492
Ccel_0550
PFAM: UBA/THIF-type NAD/FAD binding protein; KEGG: cth:Cthe_3110 UBA/ThiF-type NAD/FAD binding fold.
  
     0.474
Ccel_0179
PFAM: NUDIX hydrolase; KEGG: aoe:Clos_1784 NUDIX hydrolase.
       0.448
Your Current Organism:
Ruminiclostridium cellulolyticum
NCBI taxonomy Id: 394503
Other names: Clostridium cellulolyticum H10, R. cellulolyticum H10, Ruminiclostridium cellulolyticum H10
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