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Ccel_0177Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (167 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 0.956
Ccel_1353
Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
 0.952
Ccel_0702
TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: ATP-cone domain protein; KEGG: dsy:DSY0397 anaerobic ribonucleoside triphosphate reductase.
    
 0.935
Ccel_0261
PFAM: CMP/dCMP deaminase zinc-binding; KEGG: cth:Cthe_2599 CMP/dCMP deaminase, zinc-binding.
  
 0.934
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
 
 0.933
tmk-2
Thymidylate kinase-like protein; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
 
 0.933
Ccel_1803
PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; KEGG: cth:Cthe_2359 metal dependent phosphohydrolase.
  
 
 0.910
Ccel_1174
PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: pmy:Pmen_1038 metallophosphoesterase; Belongs to the 5'-nucleotidase family.
     
  0.900
Ccel_2519
PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: afl:Aflv_2607 protein UshA precursor (two S-layer domains; UDP-sugar hydrolase; 5'-nucleotidase); Belongs to the 5'-nucleotidase family.
     
  0.900
Ccel_3188
PFAM: flavoprotein; KEGG: efa:EF2656 phosphopantothenoylcysteine decarboxylase.
 
  
 0.870
Your Current Organism:
Ruminiclostridium cellulolyticum
NCBI taxonomy Id: 394503
Other names: Clostridium cellulolyticum H10, R. cellulolyticum H10, Ruminiclostridium cellulolyticum H10
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