Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Ccel_0341PFAM: PilT protein domain protein; deoxyribonuclease/rho motif-related TRAM; SMART: Nucleotide binding protein PINc; KEGG: nth:Nther_0165 PilT protein domain protein. (346 aa)    
Predicted Functional Partners:
ispD
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
  
    0.867
Ccel_0340
PFAM: transcription factor CarD; KEGG: cth:Cthe_2940 CarD family transcriptional regulator.
       0.757
Ccel_0336
AAA ATPase; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
  
  
 0.693
Ccel_0343
PFAM: ABC transporter transmembrane region; ABC transporter related; SMART: AAA ATPase; KEGG: cac:CAC1558 ABC-type transport system,membrane ATPase component.
       0.624
Ccel_0324
Transcriptional repressor, CtsR; PFAM: Firmicute transcriptional repressor of class III stress genes; KEGG: cth:Cthe_1792 firmicute transcriptional repressor of class III stress genes; Belongs to the CtsR family.
 
    0.530
disA
Protein of unknown function DUF147; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
  
  
 0.517
Ccel_0325
PFAM: UvrB/UvrC protein; KEGG: cth:Cthe_1791 UvrB/UvrC protein.
 
    0.506
mcsB
ATP:guanido phosphotransferase; Catalyzes the specific phosphorylation of arginine residues in proteins.
 
    0.495
Ccel_0339
KEGG: cth:Cthe_1784 hypothetical protein.
       0.473
Ccel_0003
PFAM: RNA-binding S4 domain protein; KEGG: cpr:CPR_0003 S4 domain-containing protein.
   
    0.446
Your Current Organism:
Ruminiclostridium cellulolyticum
NCBI taxonomy Id: 394503
Other names: Clostridium cellulolyticum H10, R. cellulolyticum H10, Ruminiclostridium cellulolyticum H10
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.