node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ccel_1042 | hisA | Ccel_1042 | Ccel_0387 | PFAM: aminotransferase class I and II; KEGG: cdf:CD1549 putative histidinol-phosphate aminotransferase. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: cth:Cthe_2887 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.882 |
Ccel_1042 | hisB | Ccel_1042 | Ccel_0384 | PFAM: aminotransferase class I and II; KEGG: cdf:CD1549 putative histidinol-phosphate aminotransferase. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: cth:Cthe_2884 imidazoleglycerol-phosphate dehydratase. | 0.991 |
Ccel_1042 | hisC | Ccel_1042 | Ccel_0383 | PFAM: aminotransferase class I and II; KEGG: cdf:CD1549 putative histidinol-phosphate aminotransferase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class V; aminotransferase class I and II; KEGG: cth:Cthe_2883 histidinol phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.928 |
Ccel_1042 | hisD | Ccel_1042 | Ccel_0382 | PFAM: aminotransferase class I and II; KEGG: cdf:CD1549 putative histidinol-phosphate aminotransferase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.922 |
Ccel_1042 | hisF | Ccel_1042 | Ccel_0388 | PFAM: aminotransferase class I and II; KEGG: cdf:CD1549 putative histidinol-phosphate aminotransferase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.913 |
Ccel_1042 | hisG | Ccel_1042 | Ccel_0381 | PFAM: aminotransferase class I and II; KEGG: cdf:CD1549 putative histidinol-phosphate aminotransferase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.863 |
Ccel_1042 | hisH | Ccel_1042 | Ccel_0386 | PFAM: aminotransferase class I and II; KEGG: cdf:CD1549 putative histidinol-phosphate aminotransferase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.918 |
Ccel_1042 | hisI | Ccel_1042 | Ccel_0389 | PFAM: aminotransferase class I and II; KEGG: cdf:CD1549 putative histidinol-phosphate aminotransferase. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: cth:Cthe_2889 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; In the N-terminal section; belongs to the PRA-CH family. | 0.995 |
Ccel_1042 | hisZ | Ccel_1042 | Ccel_0380 | PFAM: aminotransferase class I and II; KEGG: cdf:CD1549 putative histidinol-phosphate aminotransferase. | histidyl-tRNA synthetase 2; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.666 |
Ccel_1287 | hisA | Ccel_1287 | Ccel_0387 | PFAM: aminotransferase class I and II; Allinase-like; KEGG: cbk:CLL_A2918 threonine-phosphate decarboxylase. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: cth:Cthe_2887 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.774 |
Ccel_1287 | hisB | Ccel_1287 | Ccel_0384 | PFAM: aminotransferase class I and II; Allinase-like; KEGG: cbk:CLL_A2918 threonine-phosphate decarboxylase. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: cth:Cthe_2884 imidazoleglycerol-phosphate dehydratase. | 0.916 |
Ccel_1287 | hisD | Ccel_1287 | Ccel_0382 | PFAM: aminotransferase class I and II; Allinase-like; KEGG: cbk:CLL_A2918 threonine-phosphate decarboxylase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.913 |
Ccel_1287 | hisF | Ccel_1287 | Ccel_0388 | PFAM: aminotransferase class I and II; Allinase-like; KEGG: cbk:CLL_A2918 threonine-phosphate decarboxylase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.836 |
Ccel_1287 | hisG | Ccel_1287 | Ccel_0381 | PFAM: aminotransferase class I and II; Allinase-like; KEGG: cbk:CLL_A2918 threonine-phosphate decarboxylase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.735 |
Ccel_1287 | hisH | Ccel_1287 | Ccel_0386 | PFAM: aminotransferase class I and II; Allinase-like; KEGG: cbk:CLL_A2918 threonine-phosphate decarboxylase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.818 |
Ccel_1287 | hisI | Ccel_1287 | Ccel_0389 | PFAM: aminotransferase class I and II; Allinase-like; KEGG: cbk:CLL_A2918 threonine-phosphate decarboxylase. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: cth:Cthe_2889 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; In the N-terminal section; belongs to the PRA-CH family. | 0.991 |
Ccel_1287 | hisZ | Ccel_1287 | Ccel_0380 | PFAM: aminotransferase class I and II; Allinase-like; KEGG: cbk:CLL_A2918 threonine-phosphate decarboxylase. | histidyl-tRNA synthetase 2; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.689 |
hisA | Ccel_1042 | Ccel_0387 | Ccel_1042 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: cth:Cthe_2887 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | PFAM: aminotransferase class I and II; KEGG: cdf:CD1549 putative histidinol-phosphate aminotransferase. | 0.882 |
hisA | Ccel_1287 | Ccel_0387 | Ccel_1287 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: cth:Cthe_2887 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | PFAM: aminotransferase class I and II; Allinase-like; KEGG: cbk:CLL_A2918 threonine-phosphate decarboxylase. | 0.774 |
hisA | hisB | Ccel_0387 | Ccel_0384 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: cth:Cthe_2887 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: cth:Cthe_2884 imidazoleglycerol-phosphate dehydratase. | 0.997 |