Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
polCDNA polymerase III, alpha subunit; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1433 aa)    
Predicted Functional Partners:
dnaX
DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
  
 0.948
Ccel_0002
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
    
 0.940
Ccel_1954
TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; KEGG: cth:Cthe_1040 DNA polymerase III, delta subunit.
    
 0.934
Ccel_1459
DNA polymerase III, alpha subunit; KEGG: cth:Cthe_1264 DNA polymerase III DnaE; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; DNA polymerase III alpha subunit; SMART: phosphoesterase PHP domain protein.
    
0.932
Ccel_0159
KEGG: cth:Cthe_2105 DNA polymerase III, delta prime subunit.
   
 0.916
ispG
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family.
       0.654
Ccel_0450
TIGRFAM: membrane-associated zinc metalloprotease; PFAM: PDZ/DHR/GLGF domain protein; peptidase M50; KEGG: cth:Cthe_0998 peptidase RseP.
  
    0.652
nusA
NusA antitermination factor; Participates in both transcription termination and antitermination.
 
    0.638
rimP
Protein of unknown function DUF150; Required for maturation of 30S ribosomal subunits. Belongs to the RimP family.
  
  
 0.612
Ccel_1364
KEGG: ctc:CTC02054 metal dependent phosphohydrolase; TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region.
  
     0.611
Your Current Organism:
Ruminiclostridium cellulolyticum
NCBI taxonomy Id: 394503
Other names: Clostridium cellulolyticum H10, R. cellulolyticum H10, Ruminiclostridium cellulolyticum H10
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