Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Ccel_0635PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: cac:CAC3420 low specificity L-threonine aldolase. (344 aa)    
Predicted Functional Partners:
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
   
 0.943
Ccel_1450
TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: cth:Cthe_1381 threonine synthase.
    
 0.929
Ccel_1149
PFAM: Methyltransferase type 11; Methyltransferase type 12; Tellurite resistance methyltransferase, TehB, core; KEGG: cth:Cthe_1959 methyltransferase type 11.
     
  0.900
Ccel_0634
KEGG: ckl:CKL_2293 hypothetical protein.
       0.507
Ccel_0636
KEGG: cth:Cthe_2177 hypothetical protein.
       0.465
Ccel_2006
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
      
 0.434
Ccel_3198
PFAM: iron-containing alcohol dehydrogenase; Aldehyde Dehydrogenase; KEGG: cdf:CD2966 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
     
 0.434
Ccel_1435
SMART: AAA ATPase; KEGG: cth:Cthe_0332 phosphoribulokinase/uridine kinase.
 
    0.406
Your Current Organism:
Ruminiclostridium cellulolyticum
NCBI taxonomy Id: 394503
Other names: Clostridium cellulolyticum H10, R. cellulolyticum H10, Ruminiclostridium cellulolyticum H10
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