node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ccel_0327 | clpP | Ccel_0327 | Ccel_0810 | PFAM: UvrB/UvrC protein; AAA ATPase central domain protein; Clp domain protein; Torsin; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_1789 ATPase AAA-2; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.871 |
Ccel_0327 | clpX | Ccel_0327 | Ccel_0811 | PFAM: UvrB/UvrC protein; AAA ATPase central domain protein; Clp domain protein; Torsin; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_1789 ATPase AAA-2; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.453 |
Ccel_0327 | dnaK | Ccel_0327 | Ccel_1798 | PFAM: UvrB/UvrC protein; AAA ATPase central domain protein; Clp domain protein; Torsin; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_1789 ATPase AAA-2; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.959 |
Ccel_0327 | groL | Ccel_0327 | Ccel_0392 | PFAM: UvrB/UvrC protein; AAA ATPase central domain protein; Clp domain protein; Torsin; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_1789 ATPase AAA-2; Belongs to the ClpA/ClpB family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.717 |
Ccel_0327 | groS | Ccel_0327 | Ccel_0391 | PFAM: UvrB/UvrC protein; AAA ATPase central domain protein; Clp domain protein; Torsin; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_1789 ATPase AAA-2; Belongs to the ClpA/ClpB family. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.738 |
Ccel_0327 | grpE | Ccel_0327 | Ccel_1799 | PFAM: UvrB/UvrC protein; AAA ATPase central domain protein; Clp domain protein; Torsin; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_1789 ATPase AAA-2; Belongs to the ClpA/ClpB family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.874 |
Ccel_0327 | hrcA | Ccel_0327 | Ccel_1800 | PFAM: UvrB/UvrC protein; AAA ATPase central domain protein; Clp domain protein; Torsin; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_1789 ATPase AAA-2; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.674 |
Ccel_2116 | clpP | Ccel_2116 | Ccel_0810 | PFAM: AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_0312 ATPase AAA-2; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.873 |
Ccel_2116 | clpX | Ccel_2116 | Ccel_0811 | PFAM: AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_0312 ATPase AAA-2; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.453 |
Ccel_2116 | dnaK | Ccel_2116 | Ccel_1798 | PFAM: AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_0312 ATPase AAA-2; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.959 |
Ccel_2116 | groL | Ccel_2116 | Ccel_0392 | PFAM: AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_0312 ATPase AAA-2; Belongs to the ClpA/ClpB family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.717 |
Ccel_2116 | groS | Ccel_2116 | Ccel_0391 | PFAM: AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_0312 ATPase AAA-2; Belongs to the ClpA/ClpB family. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.738 |
Ccel_2116 | grpE | Ccel_2116 | Ccel_1799 | PFAM: AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_0312 ATPase AAA-2; Belongs to the ClpA/ClpB family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.871 |
Ccel_2116 | hrcA | Ccel_2116 | Ccel_1800 | PFAM: AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_0312 ATPase AAA-2; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.674 |
Ccel_2304 | clpP | Ccel_2304 | Ccel_0810 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; 4Fe-4S ferredoxin, iron-sulphur binding, conserved site; KEGG: aoe:Clos_0989 NADH dehydrogenase (quinone). | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.720 |
Ccel_2304 | dnaK | Ccel_2304 | Ccel_1798 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; 4Fe-4S ferredoxin, iron-sulphur binding, conserved site; KEGG: aoe:Clos_0989 NADH dehydrogenase (quinone). | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.564 |
Ccel_2304 | groL | Ccel_2304 | Ccel_0392 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; 4Fe-4S ferredoxin, iron-sulphur binding, conserved site; KEGG: aoe:Clos_0989 NADH dehydrogenase (quinone). | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.520 |
clpP | Ccel_0327 | Ccel_0810 | Ccel_0327 | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | PFAM: UvrB/UvrC protein; AAA ATPase central domain protein; Clp domain protein; Torsin; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_1789 ATPase AAA-2; Belongs to the ClpA/ClpB family. | 0.871 |
clpP | Ccel_2116 | Ccel_0810 | Ccel_2116 | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | PFAM: AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_0312 ATPase AAA-2; Belongs to the ClpA/ClpB family. | 0.873 |
clpP | Ccel_2304 | Ccel_0810 | Ccel_2304 | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; 4Fe-4S ferredoxin, iron-sulphur binding, conserved site; KEGG: aoe:Clos_0989 NADH dehydrogenase (quinone). | 0.720 |