Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Ccel_1307PFAM: glycosyl transferase family 2; KEGG: cth:Cthe_3094 glycosyl transferase family protein. (321 aa)    
Predicted Functional Partners:
Ccel_1308
KEGG: btk:BT9727_5109 hypothetical protein.
 
  
 0.857
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
  
 0.568
Ccel_1310
Dihydrofolate reductase region; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
     
 0.560
Ccel_0262
PFAM: glycosyl transferase family 4; UDP-N-acetylglucosamine 2-epimerase; KEGG: cth:Cthe_2601 UDP-N-acetylglucosamine 2-epimerase.
  
  
 0.552
Ccel_2331
TIGRFAM: amino acid adenylation domain protein; PFAM: AMP-dependent synthetase and ligase; condensation domain protein; short-chain dehydrogenase/reductase SDR; phosphopantetheine-binding; KR domain protein; Beta-ketoacyl synthase; KEGG: bsu:BSU17180 polyketide synthase of type I.
  
 
 0.551
Ccel_1306
PFAM: phosphoesterase PA-phosphatase related; KEGG: cno:NT01CX_1615 PAP2 family protein, putative.
     
 0.516
Ccel_0350
PFAM: GtrA family protein; KEGG: pdi:BDI_1652 putative GtrA family protein.
 
  
 0.483
Ccel_1305
KEGG: cpf:CPF_1142 hypothetical protein.
       0.439
Ccel_2883
PFAM: glycosyl transferase group 1; polysaccharide pyruvyl transferase; KEGG: cth:Cthe_2702 polysaccharide pyruvyl transferase.
  
  
 0.432
Ccel_1304
KEGG: mla:Mlab_1595 hypothetical protein.
       0.407
Your Current Organism:
Ruminiclostridium cellulolyticum
NCBI taxonomy Id: 394503
Other names: Clostridium cellulolyticum H10, R. cellulolyticum H10, Ruminiclostridium cellulolyticum H10
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