node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ccel_0084 | Ccel_0394 | Ccel_0084 | Ccel_0394 | TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: cth:Cthe_2254 hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase; KEGG: dsy:DSY2052 inositol-5-monophosphate dehydrogenase. | 0.926 |
Ccel_0084 | Ccel_1080 | Ccel_0084 | Ccel_1080 | TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: cth:Cthe_2254 hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | PFAM: PfkB domain protein; KEGG: cbt:CLH_3246 kinase, PfkB family. | 0.905 |
Ccel_0084 | Ccel_1174 | Ccel_0084 | Ccel_1174 | TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: cth:Cthe_2254 hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: pmy:Pmen_1038 metallophosphoesterase; Belongs to the 5'-nucleotidase family. | 0.902 |
Ccel_0084 | Ccel_1353 | Ccel_0084 | Ccel_1353 | TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: cth:Cthe_2254 hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.906 |
Ccel_0084 | Ccel_2519 | Ccel_0084 | Ccel_2519 | TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: cth:Cthe_2254 hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: afl:Aflv_2607 protein UshA precursor (two S-layer domains; UDP-sugar hydrolase; 5'-nucleotidase); Belongs to the 5'-nucleotidase family. | 0.902 |
Ccel_0084 | apt | Ccel_0084 | Ccel_1952 | TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: cth:Cthe_2254 hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.929 |
Ccel_0084 | deoD | Ccel_0084 | Ccel_3381 | TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: cth:Cthe_2254 hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | TIGRFAM: purine nucleoside phosphorylase; PFAM: purine or other phosphorylase family 1; KEGG: cpy:Cphy_0752 purine nucleoside phosphorylase. | 0.915 |
Ccel_0084 | gmk | Ccel_0084 | Ccel_1791 | TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: cth:Cthe_2254 hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.915 |
Ccel_0084 | guaA | Ccel_0084 | Ccel_2202 | TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: cth:Cthe_2254 hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.974 |
Ccel_0084 | xpt | Ccel_0084 | Ccel_1405 | TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: cth:Cthe_2254 hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.921 |
Ccel_0394 | Ccel_0084 | Ccel_0394 | Ccel_0084 | PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase; KEGG: dsy:DSY2052 inositol-5-monophosphate dehydrogenase. | TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: cth:Cthe_2254 hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.926 |
Ccel_0394 | Ccel_1080 | Ccel_0394 | Ccel_1080 | PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase; KEGG: dsy:DSY2052 inositol-5-monophosphate dehydrogenase. | PFAM: PfkB domain protein; KEGG: cbt:CLH_3246 kinase, PfkB family. | 0.905 |
Ccel_0394 | Ccel_1174 | Ccel_0394 | Ccel_1174 | PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase; KEGG: dsy:DSY2052 inositol-5-monophosphate dehydrogenase. | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: pmy:Pmen_1038 metallophosphoesterase; Belongs to the 5'-nucleotidase family. | 0.908 |
Ccel_0394 | Ccel_1353 | Ccel_0394 | Ccel_1353 | PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase; KEGG: dsy:DSY2052 inositol-5-monophosphate dehydrogenase. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.946 |
Ccel_0394 | Ccel_2519 | Ccel_0394 | Ccel_2519 | PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase; KEGG: dsy:DSY2052 inositol-5-monophosphate dehydrogenase. | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: afl:Aflv_2607 protein UshA precursor (two S-layer domains; UDP-sugar hydrolase; 5'-nucleotidase); Belongs to the 5'-nucleotidase family. | 0.908 |
Ccel_0394 | apt | Ccel_0394 | Ccel_1952 | PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase; KEGG: dsy:DSY2052 inositol-5-monophosphate dehydrogenase. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.598 |
Ccel_0394 | gmk | Ccel_0394 | Ccel_1791 | PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase; KEGG: dsy:DSY2052 inositol-5-monophosphate dehydrogenase. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.425 |
Ccel_0394 | guaA | Ccel_0394 | Ccel_2202 | PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase; KEGG: dsy:DSY2052 inositol-5-monophosphate dehydrogenase. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.999 |
Ccel_0394 | xpt | Ccel_0394 | Ccel_1405 | PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase; KEGG: dsy:DSY2052 inositol-5-monophosphate dehydrogenase. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.964 |
Ccel_1080 | Ccel_0084 | Ccel_1080 | Ccel_0084 | PFAM: PfkB domain protein; KEGG: cbt:CLH_3246 kinase, PfkB family. | TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: cth:Cthe_2254 hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.905 |