Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Ccel_1685KEGG: cbl:CLK_1174 hypothetical protein. (91 aa)    
Predicted Functional Partners:
Ccel_1686
PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; NADH ubiquinone oxidoreductase 20 kDa subunit; KEGG: rci:RCIX2382 hydrogenase, small subunit-like protein (HycG-like).
       0.773
Ccel_1687
PFAM: NADH dehydrogenase (ubiquinone) 30 kDa subunit; KEGG: rci:RCIX2383 hydrogenase, large subunit-like protein (HycE-like).
       0.705
Ccel_1688
PFAM: NADH/Ubiquinone/plastoquinone (complex I); KEGG: rci:RCIX2384 hydrogenase, membrane subunit 1-like protein (EchA-like).
       0.705
Ccel_1689
KEGG: rci:RCIX2385 hydrogenase, membrane subunit 2-like protein.
       0.637
Ccel_1690
KEGG: rpd:RPD_3854 respiratory-chain NADH dehydrogenase, subunit 1.
       0.581
Ccel_1684
PFAM: aminotransferase class V; KEGG: cth:Cthe_1064 aminotransferase, class V.
       0.567
thiI
Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
       0.557
Ccel_1691
PFAM: NADH/Ubiquinone/plastoquinone (complex I); KEGG: rci:RCIX2387 hydrogenase, membrane subunit 4-like protein (HycC-like).
       0.522
lexA
SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
       0.403
Your Current Organism:
Ruminiclostridium cellulolyticum
NCBI taxonomy Id: 394503
Other names: Clostridium cellulolyticum H10, R. cellulolyticum H10, Ruminiclostridium cellulolyticum H10
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