Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
Ccel_1734Transcriptional regulator, RpiR family; PFAM: helix-turn-helix protein RpiR; sugar isomerase (SIS); KEGG: cth:Cthe_0706 RpiR family transcriptional regulator. (297 aa)    
Predicted Functional Partners:
Ccel_1733
HI0933 family protein; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; HI0933 family protein; FAD dependent oxidoreductase; KEGG: cth:Cthe_0708 FAD dependent oxidoreductase.
       0.776
Ccel_1735
KEGG: cth:Cthe_0704 hypothetical protein.
       0.537
Ccel_1732
KEGG: cth:Cthe_0709 hypothetical protein.
       0.525
Ccel_1522
PFAM: single-strand binding protein/Primosomal replication protein n; KEGG: cth:Cthe_0559 single-strand DNA-binding protein.
  
     0.490
Ccel_1326
KEGG: cth:Cthe_0165 hypothetical protein.
  
     0.484
ispH
Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.
       0.479
Ccel_0042
TIGRFAM: primosome, DnaD subunit; PFAM: DnaD and phage-associated region; KEGG: cth:Cthe_2419 DNA replication protein DnaD.
  
     0.475
Ccel_1464
KEGG: cpy:Cphy_0207 hypothetical protein.
  
     0.453
birA
biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
      
 0.448
ecfT
Cobalt transport protein; Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
  
    0.437
Your Current Organism:
Ruminiclostridium cellulolyticum
NCBI taxonomy Id: 394503
Other names: Clostridium cellulolyticum H10, R. cellulolyticum H10, Ruminiclostridium cellulolyticum H10
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