Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Ccel_1895KEGG: cth:Cthe_0813 SpoIVB peptidase; TIGRFAM: stage IV sporulation protein B; PFAM: peptidase S55 SpoIVB; SMART: PDZ/DHR/GLGF domain protein. (441 aa)    
Predicted Functional Partners:
Ccel_1894
Sporulation transcriptional activator Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
   
 0.911
gpr
Spore protease; Initiates the rapid degradation of small, acid-soluble proteins during spore germination; Belongs to the peptidase A25 family.
  
    0.830
spoIIAB
Anti-sigma regulatory factor, serine/threonine protein kinase; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
  
   
 0.830
Ccel_1912
TIGRFAM: stage III sporulation protein AE; PFAM: Sporulation stage III protein AE; KEGG: cth:Cthe_0841 mutants block sporulation after engulfment.
 
   
 0.803
Ccel_2282
TIGRFAM: stage V sporulation protein AC; PFAM: SpoVA protein; KEGG: cth:Cthe_0122 SpoVA protein.
  
   
 0.803
Ccel_2281
TIGRFAM: stage V sporulation protein AD; PFAM: Stage V sporulation AD family protein; KEGG: cth:Cthe_0123 stage V sporulation protein AD.
  
  
 0.802
Ccel_2280
TIGRFAM: stage V sporulation protein AE; PFAM: SpoVA protein; KEGG: cth:Cthe_0124 SpoVA protein.
  
   
 0.801
Ccel_1913
TIGRFAM: stage III sporulation protein AD; PFAM: Sporulation stage III protein AD; KEGG: cth:Cthe_0842 stage III sporulation protein AD.
 
   
 0.799
Ccel_1916
TIGRFAM: stage III sporulation protein AA; SMART: AAA ATPase; KEGG: cth:Cthe_0845 stage III sporulation protein spoIIIAA.
 
   
 0.794
Ccel_1944
TIGRFAM: stage II sporulation protein P; PFAM: Stage II sporulation P family protein; KEGG: cth:Cthe_1328 stage II sporulation P.
  
   
 0.794
Your Current Organism:
Ruminiclostridium cellulolyticum
NCBI taxonomy Id: 394503
Other names: Clostridium cellulolyticum H10, R. cellulolyticum H10, Ruminiclostridium cellulolyticum H10
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