Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Ccel_1944TIGRFAM: stage II sporulation protein P; PFAM: Stage II sporulation P family protein; KEGG: cth:Cthe_1328 stage II sporulation P. (407 aa)    
Predicted Functional Partners:
Ccel_2986
KEGG: cth:Cthe_2681 serine phosphatase; TIGRFAM: stage II sporulation protein E; PFAM: Stage II sporulation E family protein; SMART: protein phosphatase 2C domain protein.
  
   
 0.845
Ccel_0292
TIGRFAM: stage II sporulation protein R; PFAM: Sporulation stage II protein R; KEGG: cth:Cthe_1920 stage II sporulation protein R.
  
   
 0.843
spoIIAB
Anti-sigma regulatory factor, serine/threonine protein kinase; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
  
   
 0.838
Ccel_1909
KEGG: cth:Cthe_0838 hypothetical protein.
  
   
 0.832
Ccel_2063
sigma-E processing peptidase SpoIIGA; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family.
  
   
 0.826
Ccel_1916
TIGRFAM: stage III sporulation protein AA; SMART: AAA ATPase; KEGG: cth:Cthe_0845 stage III sporulation protein spoIIIAA.
  
   
 0.823
Ccel_1914
TIGRFAM: stage III sporulation protein AC; PFAM: Stage III sporulation AC family protein; KEGG: cth:Cthe_0843 stage III sporulation AC.
  
  
 0.822
gpr
Spore protease; Initiates the rapid degradation of small, acid-soluble proteins during spore germination; Belongs to the peptidase A25 family.
 
  
 0.818
Ccel_1910
KEGG: cth:Cthe_0839 stage III sporulation protein AG.
  
  
 0.803
Ccel_0573
TIGRFAM: sporulation protein YqfD; PFAM: putative stage IV sporulation YqfD; KEGG: cth:Cthe_1072 putative stage IV sporulation YqfD.
  
   
 0.798
Your Current Organism:
Ruminiclostridium cellulolyticum
NCBI taxonomy Id: 394503
Other names: Clostridium cellulolyticum H10, R. cellulolyticum H10, Ruminiclostridium cellulolyticum H10
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