Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Ccel_2018KEGG: cth:Cthe_0501 hypothetical protein. (176 aa)    
Predicted Functional Partners:
Ccel_2019
KEGG: cth:Cthe_0500 hypothetical protein.
       0.654
Ccel_2020
KEGG: cth:Cthe_0499 hypothetical protein.
       0.557
Ccel_2022
TIGRFAM: RNA polymerase sigma factor, FliA/WhiG family; RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 3 domain protein; sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: cth:Cthe_0495 RNA polymerase, sigma 28 subunit.
       0.524
aroE
Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
  
    0.495
Ccel_1435
SMART: AAA ATPase; KEGG: cth:Cthe_0332 phosphoribulokinase/uridine kinase.
  
    0.495
Ccel_0478
PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain; PASTA domain containing protein; KEGG: cth:Cthe_0979 peptidoglycan glycosyltransferase.
  
  
 0.447
Ccel_2021
PFAM: protein of unknown function DUF342; KEGG: cth:Cthe_0498 hypothetical protein.
       0.439
cheD
CheD; Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis; Belongs to the CheD family.
       0.413
Ccel_2025
PFAM: CheC domain protein; KEGG: cth:Cthe_0492 CheC, inhibitor of MCP methylation.
       0.404
Ccel_2038
CheC, inhibitor of MCP methylation / FliN fusion protein; TIGRFAM: flagellar motor switch protein FliN; PFAM: surface presentation of antigens (SPOA) protein; CheC domain protein; KEGG: cth:Cthe_0478 flagellar motor switch protein.
     
 0.400
Your Current Organism:
Ruminiclostridium cellulolyticum
NCBI taxonomy Id: 394503
Other names: Clostridium cellulolyticum H10, R. cellulolyticum H10, Ruminiclostridium cellulolyticum H10
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