Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Ccel_2095PFAM: histidine triad (HIT) protein; KEGG: cth:Cthe_1369 histidine triad (HIT) protein. (114 aa)    
Predicted Functional Partners:
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
 
 
   0.792
cobB
Silent information regulator protein Sir2; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily.
  
 
  0.731
Ccel_1435
SMART: AAA ATPase; KEGG: cth:Cthe_0332 phosphoribulokinase/uridine kinase.
   
 0.651
rpsU
PFAM: ribosomal protein S21; KEGG: cth:Cthe_1348 SSU ribosomal protein S21P; Belongs to the bacterial ribosomal protein bS21 family.
  
    0.574
Ccel_2093
PFAM: GatB/Yqey domain protein; KEGG: cth:Cthe_1347 GatB/YqeY.
     
 0.523
lysS
TIGRFAM: lysyl-tRNA synthetase; PFAM: tRNA synthetase class II (D K and N); nucleic acid binding OB-fold tRNA/helicase-type; KEGG: tpd:Teth39_0318 lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family.
   
 0.462
Ccel_2091
PFAM: protein of unknown function UPF0153; KEGG: mms:mma_2931 hypothetical protein.
  
 
 0.460
Ccel_2090
PFAM: ThiJ/PfpI domain protein; KEGG: cbe:Cbei_3829 ThiJ/PfpI domain protein.
  
 
 0.457
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
   
 
 0.443
Ccel_1637
Hypothetical protein; KEGG: cth:Cthe_0351 PpiC-type peptidyl-prolyl cis-trans isomerase.
  
   0.438
Your Current Organism:
Ruminiclostridium cellulolyticum
NCBI taxonomy Id: 394503
Other names: Clostridium cellulolyticum H10, R. cellulolyticum H10, Ruminiclostridium cellulolyticum H10
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.