Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Ccel_2116PFAM: AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_0312 ATPase AAA-2; Belongs to the ClpA/ClpB family. (781 aa)    
Predicted Functional Partners:
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.959
clpP
ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
  
 
 0.865
Ccel_2938
PFAM: heat shock protein Hsp20; KEGG: cbe:Cbei_4123 heat shock protein HSP20; Belongs to the small heat shock protein (HSP20) family.
 
 
 0.864
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
 
 
 0.863
Ccel_2566
PFAM: Negative regulator of genetic competence; KEGG: cth:Cthe_0085 negative regulator of genetic competence.
    
 
 0.852
Ccel_2835
PFAM: peptidase S14 ClpP; KEGG: bca:BCE_0399 ClpP protease family protein; Belongs to the peptidase S14 family.
   
 
 0.830
Ccel_0492
PFAM: heat shock protein Hsp90; ATP-binding region ATPase domain protein; KEGG: cth:Cthe_0550 heat shock protein 90.
  
 
 0.821
mcsB
ATP:guanido phosphotransferase; Catalyzes the specific phosphorylation of arginine residues in proteins.
  
 
 0.764
Ccel_1703
PFAM: peptidase S14 ClpP; KEGG: cth:Cthe_1097 ATP-dependent Clp protease proteolytic subunit ClpP.
   
 
 0.737
Ccel_0325
PFAM: UvrB/UvrC protein; KEGG: cth:Cthe_1791 UvrB/UvrC protein.
 
  
 0.729
Your Current Organism:
Ruminiclostridium cellulolyticum
NCBI taxonomy Id: 394503
Other names: Clostridium cellulolyticum H10, R. cellulolyticum H10, Ruminiclostridium cellulolyticum H10
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