Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Ccel_2145Histidine kinase; PFAM: ATP-binding region ATPase domain protein; KEGG: cth:Cthe_2944 periplasmic sensor signal transduction histidine kinase. (610 aa)    
Predicted Functional Partners:
Ccel_2425
PFAM: response regulator receiver; KEGG: cth:Cthe_3087 response regulator receiver protein.
  
  
 0.938
Ccel_2146
Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein; response regulator receiver; KEGG: cth:Cthe_0725 response regulator receiver modulated metal dependent phosphohydrolase.
 
 
 0.934
Ccel_1894
Sporulation transcriptional activator Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
     
 0.902
Ccel_0239
Hypothetical protein; KEGG: LOC100083241; similar to vitellogenin.
  
     0.720
Ccel_1937
PFAM: copper amine oxidase domain protein; KEGG: cth:Cthe_0243 copper amine oxidase-like protein.
 
  
 0.648
Ccel_0029
Hypothetical protein; KEGG: hau:Haur_4114 multi-sensor signal transduction histidine kinase.
  
     0.627
Ccel_0728
PFAM: type 3a cellulose-binding domain protein; cellulosome anchoring protein cohesin region; protein of unknown function DUF291; KEGG: cth:Cthe_3077 cellulosome anchoring protein, cohesin region.
  
     0.621
Ccel_2442
PFAM: cellulosome protein dockerin type I; KEGG: gvi:gll3705 unknown protein.
  
     0.618
Ccel_0277
PFAM: Fibronectin type III domain protein; KEGG: cth:Cthe_2612 fibronectin, type III.
  
     0.616
Ccel_0509
KEGG: cth:Cthe_1830 hypothetical protein.
  
  
 0.600
Your Current Organism:
Ruminiclostridium cellulolyticum
NCBI taxonomy Id: 394503
Other names: Clostridium cellulolyticum H10, R. cellulolyticum H10, Ruminiclostridium cellulolyticum H10
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