Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
Ccel_2164PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: amt:Amet_4132 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (182 aa)    
Predicted Functional Partners:
folD
Tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.925
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
  
 
 0.921
Ccel_1860
PFAM: Rhomboid family protein; KEGG: cth:Cthe_1048 rhomboid family protein.
  
  
 0.692
Ccel_2165
KEGG: cth:Cthe_1296 hypothetical protein.
       0.679
pheT
TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; KEGG: cbb:CLD_1411 phenylalanyl-tRNA synthetase, beta subunit.
  
  
 0.539
Ccel_2474
PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: ckl:CKL_1762 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein.
     
 0.486
Ccel_2166
KEGG: cth:Cthe_1299 hypothetical protein.
       0.484
Ccel_2163
Hypothetical protein.
       0.466
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
 
     0.424
fhs
PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: cth:Cthe_2399 formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.
   
 
 0.421
Your Current Organism:
Ruminiclostridium cellulolyticum
NCBI taxonomy Id: 394503
Other names: Clostridium cellulolyticum H10, R. cellulolyticum H10, Ruminiclostridium cellulolyticum H10
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