Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
larCProtein of unknown function DUF111; Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes. Belongs to the LarC family. (432 aa)    
Predicted Functional Partners:
Ccel_2205
PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; KEGG: cth:Cthe_0368 NCAIR mutase (PurE)-related protein.
 
  
 0.975
Ccel_0923
PFAM: ExsB family protein; KEGG: cth:Cthe_1841 hypothetical protein.
  
 0.946
Ccel_2203
Conserved hypothetical protein; KEGG: cth:Cthe_0370 putative radical SAM protein; TIGRFAM: conserved hypothetical protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB.
       0.789
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
       0.658
Ccel_1183
TIGRFAM: cobalt ABC transporter, inner membrane subunit CbiQ; PFAM: cobalt transport protein; KEGG: cth:Cthe_1802 cobalt ABC transporter, inner membrane subunit CbiQ.
 
    0.570
Ccel_1182
PFAM: cobalamin (vitamin B12) biosynthesis CbiM protein; KEGG: cth:Cthe_1803 cobalamin (vitamin B12) biosynthesis CbiM protein.
 
    0.568
prfB
Hypothetical protein; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
       0.552
Ccel_0906
KEGG: mba:Mbar_A0786 hypothetical protein.
 
    0.500
cbiM
Cobalamin biosynthesis protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.
  
    0.435
Ccel_2207
TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase; sucrose-6F-phosphate phosphohydrolase; Haloacid dehalogenase domain protein hydrolase type 3; KEGG: csc:Csac_1293 Cof-like hydrolase.
       0.417
Your Current Organism:
Ruminiclostridium cellulolyticum
NCBI taxonomy Id: 394503
Other names: Clostridium cellulolyticum H10, R. cellulolyticum H10, Ruminiclostridium cellulolyticum H10
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