Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Ccel_2269Signal transduction histidine kinase regulating citrate/malate metabolism; PFAM: ATP-binding region ATPase domain protein; KEGG: cbh:CLC_1104 sensor histidine kinase. (442 aa)    
Predicted Functional Partners:
Ccel_2270
Two component transcriptional regulator, LytTR family; PFAM: response regulator receiver; LytTr DNA-binding region; KEGG: cac:CAC1581 response regulator.
 
  
 0.903
Ccel_2646
Two component transcriptional regulator, LytTR family; PFAM: response regulator receiver; LytTr DNA-binding region; KEGG: dsy:DSY1957 hypothetical protein.
 
  
 0.620
Ccel_1167
PFAM: response regulator receiver; LytTr DNA-binding region; KEGG: cdf:CD3255 two-component response regulator.
 
  
 0.560
galT
PFAM: galactose-1-phosphate uridyl transferase domain protein; KEGG: tte:TTE1929 galactose-1-phosphate uridylyltransferase.
 
     0.544
secA-2
SecA DEAD domain protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
       0.538
Ccel_3116
PFAM: response regulator receiver; LytTr DNA-binding region; KEGG: cbe:Cbei_4580 two component transcriptional regulator, LytTR family.
 
  
 0.473
Your Current Organism:
Ruminiclostridium cellulolyticum
NCBI taxonomy Id: 394503
Other names: Clostridium cellulolyticum H10, R. cellulolyticum H10, Ruminiclostridium cellulolyticum H10
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