Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Ccel_2286Anti-sigma-factor antagonist; TIGRFAM: anti-anti-sigma factor; anti-sigma F factor antagonist; PFAM: Sulfate transporter/antisigma-factor antagonist STAS; KEGG: cth:Cthe_0118 anti-sigma-factor antagonist. (113 aa)    
Predicted Functional Partners:
spoIIAB
Anti-sigma regulatory factor, serine/threonine protein kinase; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
 
 
 0.997
Ccel_2284
RNA polymerase, sigma 28 subunit, SigF; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
  
 0.908
Ccel_0400
TIGRFAM: RNA polymerase sigma factor, sigma-70 family; RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; PFAM: sigma-70 region 3 domain protein; sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; KEGG: cth:Cthe_2900 RNA polymerase, sigma 28 subunit.
  
  
 0.899
Ccel_2282
TIGRFAM: stage V sporulation protein AC; PFAM: SpoVA protein; KEGG: cth:Cthe_0122 SpoVA protein.
 
   
 0.826
Ccel_2281
TIGRFAM: stage V sporulation protein AD; PFAM: Stage V sporulation AD family protein; KEGG: cth:Cthe_0123 stage V sporulation protein AD.
 
   
 0.813
Ccel_2280
TIGRFAM: stage V sporulation protein AE; PFAM: SpoVA protein; KEGG: cth:Cthe_0124 SpoVA protein.
 
     0.803
Ccel_2061
RNA polymerase, sigma 28 subunit, SigG; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
   
 0.761
Ccel_0292
TIGRFAM: stage II sporulation protein R; PFAM: Sporulation stage II protein R; KEGG: cth:Cthe_1920 stage II sporulation protein R.
  
   
 0.753
Ccel_0399
KEGG: cth:Cthe_2899 putative anti-sigma regulatory factor, serine/threonine protein kinase.
 
 
 0.740
Ccel_0401
KEGG: cth:Cthe_2901 putative anti-sigma regulatory factor, serine/threonine protein kinase.
  
 
 0.697
Your Current Organism:
Ruminiclostridium cellulolyticum
NCBI taxonomy Id: 394503
Other names: Clostridium cellulolyticum H10, R. cellulolyticum H10, Ruminiclostridium cellulolyticum H10
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