Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Ccel_2474PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: ckl:CKL_1762 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. (615 aa)    
Predicted Functional Partners:
Ccel_2473
PFAM: dihydropteroate synthase DHPS; KEGG: mta:Moth_1207 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase.
 
  
 0.996
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 
 0.982
Ccel_2843
PFAM: S-adenosylmethionine synthetase; KEGG: ckl:CKL_2650 S-adenosylmethionine synthetase; Belongs to the AdoMet synthase family.
  
 
 0.982
fhs
PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: cth:Cthe_2399 formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.
  
 0.981
folD
Tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.975
metAA
Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.
  
  
 0.975
Ccel_1452
PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: cth:Cthe_1376 homoserine dehydrogenase.
  
 
 0.967
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
 
 0.966
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.962
Ccel_1962
TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: cbt:CLH_0332 O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase family protein.
  
 
 0.958
Your Current Organism:
Ruminiclostridium cellulolyticum
NCBI taxonomy Id: 394503
Other names: Clostridium cellulolyticum H10, R. cellulolyticum H10, Ruminiclostridium cellulolyticum H10
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