Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Ccel_3130TIGRFAM: transcriptional regulator, AbrB family; PFAM: SpoVT/AbrB domain protein; KEGG: cbe:Cbei_3375 transcriptional regulator, AbrB family. (80 aa)    
Predicted Functional Partners:
Ccel_3131
Hypothetical protein; KEGG: csc:Csac_2638 PKD domain-containing protein.
       0.686
Ccel_1894
Sporulation transcriptional activator Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
  
   
 0.680
Ccel_3132
PFAM: S-layer domain protein; KEGG: amt:Amet_3262 NLP/P60 protein.
       0.642
Ccel_3127
KEGG: aoe:Clos_1879 hypothetical protein.
       0.630
Ccel_3128
KEGG: aoe:Clos_1880 hypothetical protein.
       0.623
Ccel_3129
Hypothetical protein.
       0.623
spoIIAB
Anti-sigma regulatory factor, serine/threonine protein kinase; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
  
  
 0.621
Ccel_3126
PFAM: Peptidase M23; KEGG: oih:OB2491 hypothetical protein.
       0.610
Ccel_3124
KEGG: aoe:Clos_1875 hypothetical protein.
       0.602
Ccel_3125
Hypothetical protein.
       0.602
Your Current Organism:
Ruminiclostridium cellulolyticum
NCBI taxonomy Id: 394503
Other names: Clostridium cellulolyticum H10, R. cellulolyticum H10, Ruminiclostridium cellulolyticum H10
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