| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Ccel_0011 | Ccel_1084 | Ccel_0011 | Ccel_1084 | TIGRFAM: CDP-diacylglycerol/serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; KEGG: ctc:CTC01356 CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | TIGRFAM: tryptophan synthase, alpha subunit; PFAM: tryptophan synthase alpha chain; KEGG: cbt:CLH_3241 tryptophan synthase, alpha subunit. | 0.900 |
| Ccel_0011 | Ccel_2474 | Ccel_0011 | Ccel_2474 | TIGRFAM: CDP-diacylglycerol/serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; KEGG: ctc:CTC01356 CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: ckl:CKL_1762 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | 0.405 |
| Ccel_0011 | glyA | Ccel_0011 | Ccel_1680 | TIGRFAM: CDP-diacylglycerol/serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; KEGG: ctc:CTC01356 CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.900 |
| Ccel_0011 | metAA | Ccel_0011 | Ccel_3331 | TIGRFAM: CDP-diacylglycerol/serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; KEGG: ctc:CTC01356 CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.800 |
| Ccel_0011 | trpA | Ccel_0011 | Ccel_3219 | TIGRFAM: CDP-diacylglycerol/serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; KEGG: ctc:CTC01356 CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.900 |
| Ccel_0011 | trpB | Ccel_0011 | Ccel_2450 | TIGRFAM: CDP-diacylglycerol/serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; KEGG: ctc:CTC01356 CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.900 |
| Ccel_0011 | trpB-2 | Ccel_0011 | Ccel_3218 | TIGRFAM: CDP-diacylglycerol/serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; KEGG: ctc:CTC01356 CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.900 |
| Ccel_1084 | Ccel_0011 | Ccel_1084 | Ccel_0011 | TIGRFAM: tryptophan synthase, alpha subunit; PFAM: tryptophan synthase alpha chain; KEGG: cbt:CLH_3241 tryptophan synthase, alpha subunit. | TIGRFAM: CDP-diacylglycerol/serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; KEGG: ctc:CTC01356 CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.900 |
| Ccel_1084 | glyA | Ccel_1084 | Ccel_1680 | TIGRFAM: tryptophan synthase, alpha subunit; PFAM: tryptophan synthase alpha chain; KEGG: cbt:CLH_3241 tryptophan synthase, alpha subunit. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.916 |
| Ccel_1084 | metAA | Ccel_1084 | Ccel_3331 | TIGRFAM: tryptophan synthase, alpha subunit; PFAM: tryptophan synthase alpha chain; KEGG: cbt:CLH_3241 tryptophan synthase, alpha subunit. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.800 |
| Ccel_1084 | trpA | Ccel_1084 | Ccel_3219 | TIGRFAM: tryptophan synthase, alpha subunit; PFAM: tryptophan synthase alpha chain; KEGG: cbt:CLH_3241 tryptophan synthase, alpha subunit. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.922 |
| Ccel_1084 | trpB | Ccel_1084 | Ccel_2450 | TIGRFAM: tryptophan synthase, alpha subunit; PFAM: tryptophan synthase alpha chain; KEGG: cbt:CLH_3241 tryptophan synthase, alpha subunit. | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.957 |
| Ccel_1084 | trpB-2 | Ccel_1084 | Ccel_3218 | TIGRFAM: tryptophan synthase, alpha subunit; PFAM: tryptophan synthase alpha chain; KEGG: cbt:CLH_3241 tryptophan synthase, alpha subunit. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.997 |
| Ccel_1452 | Ccel_1962 | Ccel_1452 | Ccel_1962 | PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: cth:Cthe_1376 homoserine dehydrogenase. | TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: cbt:CLH_0332 O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase family protein. | 0.869 |
| Ccel_1452 | Ccel_2474 | Ccel_1452 | Ccel_2474 | PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: cth:Cthe_1376 homoserine dehydrogenase. | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: ckl:CKL_1762 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | 0.967 |
| Ccel_1452 | Ccel_3332 | Ccel_1452 | Ccel_3332 | PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: cth:Cthe_1376 homoserine dehydrogenase. | TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; DegT/DnrJ/EryC1/StrS aminotransferase; KEGG: cth:Cthe_1842 O-acetylhomoserine/O-acetylserine sulfhydrylase. | 0.869 |
| Ccel_1452 | metAA | Ccel_1452 | Ccel_3331 | PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: cth:Cthe_1376 homoserine dehydrogenase. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.945 |
| Ccel_1962 | Ccel_1452 | Ccel_1962 | Ccel_1452 | TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: cbt:CLH_0332 O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase family protein. | PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: cth:Cthe_1376 homoserine dehydrogenase. | 0.869 |
| Ccel_1962 | Ccel_2474 | Ccel_1962 | Ccel_2474 | TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: cbt:CLH_0332 O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase family protein. | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: ckl:CKL_1762 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | 0.958 |
| Ccel_1962 | Ccel_3332 | Ccel_1962 | Ccel_3332 | TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: cbt:CLH_0332 O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase family protein. | TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; DegT/DnrJ/EryC1/StrS aminotransferase; KEGG: cth:Cthe_1842 O-acetylhomoserine/O-acetylserine sulfhydrylase. | 0.904 |