STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
iscS_1Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (391 aa)    
Predicted Functional Partners:
iscU_2
Iron-sulfur cluster assembly scaffold protein IscU.
 
 0.996
iscU_1
Iron-sulfur cluster assembly scaffold protein IscU.
 
 0.985
cymR_2
HTH-type transcriptional regulator CymR.
 
 
 0.945
thiI
Putative tRNA sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
 0.924
sir
Sulfite reductase.
  
 0.883
blh
Beta-lactamase hydrolase-like protein.
 
 
 0.841
EUAN_19330
SirA-like protein; Belongs to the sulfur carrier protein TusA family.
   
 0.839
selD
Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP.
  
 0.821
mnmA_1
tRNA-specific 2-thiouridylase MnmA; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
 
  
 0.792
cysA_3
Putative thiosulfate sulfurtransferase.
   
 0.786
Your Current Organism:
Andreesenia angusta
NCBI taxonomy Id: 39480
Other names: A. angusta, ATCC 43737, Eubacterium angustum, strain MK-1
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