macB_6 protein (Faecalicatena contorta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

macB_6

Macrolide export ATP-binding/permease protein MacB. (733 aa)

Predicted Functional Partners:

lolD_8

0.961

senX3

0.901

lolD_2

0.805

lolD_10

0.774

cseB

0.771

lolD_4

0.714

lolD_1

0.703

sphS

0.701

lolD_12

0.695

lolD_3

0.690

Your Current Organism:

Faecalicatena contorta

NCBI taxonomy Id: 39482
Other names: ATCC 25540, CCUG 52236, Catenabacterium contortum, DSM 3982, Eubacterium contortum, F. contorta, JCM 6483

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
cseB	lolD_8	ERS852491_03275	ERS852491_03273	Transcriptional regulatory protein CseB.	Lipoprotein-releasing system ATP-binding protein LolD.	0.620
cseB	macB_6	ERS852491_03275	ERS852491_03272	Transcriptional regulatory protein CseB.	Macrolide export ATP-binding/permease protein MacB.	0.771
cseB	senX3	ERS852491_03275	ERS852491_03274	Transcriptional regulatory protein CseB.	Signal-transduction histidine kinase senX3.	0.966
cseB	sphS	ERS852491_03275	ERS852491_02069	Transcriptional regulatory protein CseB.	Sensor protein sphS.	0.837
lolD_1	macB_6	ERS852491_01018	ERS852491_03272	Lipoprotein-releasing system ATP-binding protein LolD.	Macrolide export ATP-binding/permease protein MacB.	0.703
lolD_10	macB_6	ERS852491_03791	ERS852491_03272	Lipoprotein-releasing system ATP-binding protein LolD.	Macrolide export ATP-binding/permease protein MacB.	0.774
lolD_10	senX3	ERS852491_03791	ERS852491_03274	Lipoprotein-releasing system ATP-binding protein LolD.	Signal-transduction histidine kinase senX3.	0.605
lolD_10	sphS	ERS852491_03791	ERS852491_02069	Lipoprotein-releasing system ATP-binding protein LolD.	Sensor protein sphS.	0.694
lolD_12	macB_6	ERS852491_04991	ERS852491_03272	Lipoprotein-releasing system ATP-binding protein LolD.	Macrolide export ATP-binding/permease protein MacB.	0.695
lolD_2	macB_6	ERS852491_02071	ERS852491_03272	Lipoprotein-releasing system ATP-binding protein LolD.	Macrolide export ATP-binding/permease protein MacB.	0.805
lolD_2	senX3	ERS852491_02071	ERS852491_03274	Lipoprotein-releasing system ATP-binding protein LolD.	Signal-transduction histidine kinase senX3.	0.607
lolD_2	sphS	ERS852491_02071	ERS852491_02069	Lipoprotein-releasing system ATP-binding protein LolD.	Sensor protein sphS.	0.692
lolD_3	macB_6	ERS852491_02078	ERS852491_03272	Lipoprotein-releasing system ATP-binding protein LolD.	Macrolide export ATP-binding/permease protein MacB.	0.690
lolD_4	macB_6	ERS852491_02104	ERS852491_03272	Lipoprotein-releasing system ATP-binding protein LolD.	Macrolide export ATP-binding/permease protein MacB.	0.714
lolD_8	cseB	ERS852491_03273	ERS852491_03275	Lipoprotein-releasing system ATP-binding protein LolD.	Transcriptional regulatory protein CseB.	0.620
lolD_8	macB_6	ERS852491_03273	ERS852491_03272	Lipoprotein-releasing system ATP-binding protein LolD.	Macrolide export ATP-binding/permease protein MacB.	0.961
lolD_8	senX3	ERS852491_03273	ERS852491_03274	Lipoprotein-releasing system ATP-binding protein LolD.	Signal-transduction histidine kinase senX3.	0.830
lolD_8	sphS	ERS852491_03273	ERS852491_02069	Lipoprotein-releasing system ATP-binding protein LolD.	Sensor protein sphS.	0.647
macB_6	cseB	ERS852491_03272	ERS852491_03275	Macrolide export ATP-binding/permease protein MacB.	Transcriptional regulatory protein CseB.	0.771
macB_6	lolD_1	ERS852491_03272	ERS852491_01018	Macrolide export ATP-binding/permease protein MacB.	Lipoprotein-releasing system ATP-binding protein LolD.	0.703

page 1 of 2

Network Stats

number of nodes:

4

number of edges:

3

average node degree:

1.5

avg. local clustering coefficient:

0.75

expected number of edges:

3

PPI enrichment p-value:

0.575

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042545

Cell wall modification

2 of 2

2.54

0.78

0.0383

GO:0005975

Carbohydrate metabolic process

6 of 259

0.91

0.5

0.0383

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045330

Aspartyl esterase activity

2 of 2

2.54

1.12

0.0092

GO:0030599

Pectinesterase activity

2 of 2

2.54

1.12

0.0092

GO:0016788

Hydrolase activity, acting on ester bonds

5 of 139

1.1

0.76

0.0081

GO:0016787

Hydrolase activity

9 of 622

0.71

0.55

0.0020

GO:0003824

Catalytic activity

11 of 1823

0.33

0.25

0.0336

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4894

Mixed, incl. Pectin lyase fold/virulence factor, and SGNH hydrolase-type esterase domain

11 of 34

2.05

6.83

1.23e-19

CL:4897

Mixed, incl. Pectin lyase fold, and Rhamnogalacturonan acetylesterase RhgT-like

7 of 15

2.21

5.15

4.70e-12

CL:4899

Pectin lyase fold, and Rhamnogalacturonan acetylesterase RhgT-like

6 of 10

2.32

4.81

1.14e-10

CL:4942

Mixed, incl. Six-hairpin glycosidase-like superfamily, and Class II aldolase/adducin N-terminal

4 of 10

2.15

2.66

4.33e-06

CL:4909

Pectin lyase fold, and Alpha/beta hydrolase fold

3 of 5

2.32

2.1

0.00010

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00040

Pentose and glucuronate interconversions

4 of 28

1.7

1.71

0.00015

map01040

Biosynthesis of unsaturated fatty acids

2 of 13

1.73

0.69

0.0450

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005576

Extracellular region

5 of 183

0.98

0.57

0.0281

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0326

Glycosidase

3 of 31

1.53

0.82

0.0195

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR037459

Rhamnogalacturonan acetylesterase RhgT-like

3 of 3

2.54

1.8

0.00048

IPR013830

SGNH hydrolase-type esterase domain

3 of 5

2.32

1.69

0.00066

IPR012334

Pectin lyase fold

3 of 6

2.24

1.68

0.00066

IPR036514

SGNH hydrolase superfamily

3 of 8

2.12

1.56

0.00097

IPR011050

Pectin lyase fold/virulence factor

3 of 9

2.07

1.54

0.0010

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00710

Parallel beta-helix repeats

2 of 5

2.15

0.94

0.0175

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