CUP00350.1 protein (Faecalicatena contorta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CUP00350.1

Protein of uncharacterised function (DUF523). (178 aa)

Predicted Functional Partners:

CUN92893.1

0.543

CUO54863.1

0.526

CUP00304.1

0.523

CUN92841.1

0.516

CUP18104.1

0.496

CUP00330.1

0.473

hgdB

0.424

Your Current Organism:

Faecalicatena contorta

NCBI taxonomy Id: 39482
Other names: ATCC 25540, CCUG 52236, Catenabacterium contortum, DSM 3982, Eubacterium contortum, F. contorta, JCM 6483

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUN92841.1	CUN92893.1	ERS852491_00849	ERS852491_00851	Uncharacterised protein.	Uncharacterised protein.	0.501
CUN92841.1	CUP00350.1	ERS852491_00849	ERS852491_03979	Uncharacterised protein.	Protein of uncharacterised function (DUF523).	0.516
CUN92841.1	CUP18104.1	ERS852491_00849	ERS852491_04478	Uncharacterised protein.	Fibronectin type III domain.	0.675
CUN92893.1	CUN92841.1	ERS852491_00851	ERS852491_00849	Uncharacterised protein.	Uncharacterised protein.	0.501
CUN92893.1	CUP00350.1	ERS852491_00851	ERS852491_03979	Uncharacterised protein.	Protein of uncharacterised function (DUF523).	0.543
CUN92893.1	CUP18104.1	ERS852491_00851	ERS852491_04478	Uncharacterised protein.	Fibronectin type III domain.	0.695
CUO54863.1	CUP00350.1	ERS852491_02549	ERS852491_03979	DNA-binding transcriptional regulator EnvR.	Protein of uncharacterised function (DUF523).	0.526
CUP00304.1	CUP00330.1	ERS852491_03977	ERS852491_03978	Ferredoxin.	Uncharacterised protein.	0.752
CUP00304.1	CUP00350.1	ERS852491_03977	ERS852491_03979	Ferredoxin.	Protein of uncharacterised function (DUF523).	0.523
CUP00330.1	CUP00304.1	ERS852491_03978	ERS852491_03977	Uncharacterised protein.	Ferredoxin.	0.752
CUP00330.1	CUP00350.1	ERS852491_03978	ERS852491_03979	Uncharacterised protein.	Protein of uncharacterised function (DUF523).	0.473
CUP00350.1	CUN92841.1	ERS852491_03979	ERS852491_00849	Protein of uncharacterised function (DUF523).	Uncharacterised protein.	0.516
CUP00350.1	CUN92893.1	ERS852491_03979	ERS852491_00851	Protein of uncharacterised function (DUF523).	Uncharacterised protein.	0.543
CUP00350.1	CUO54863.1	ERS852491_03979	ERS852491_02549	Protein of uncharacterised function (DUF523).	DNA-binding transcriptional regulator EnvR.	0.526
CUP00350.1	CUP00304.1	ERS852491_03979	ERS852491_03977	Protein of uncharacterised function (DUF523).	Ferredoxin.	0.523
CUP00350.1	CUP00330.1	ERS852491_03979	ERS852491_03978	Protein of uncharacterised function (DUF523).	Uncharacterised protein.	0.473
CUP00350.1	CUP18104.1	ERS852491_03979	ERS852491_04478	Protein of uncharacterised function (DUF523).	Fibronectin type III domain.	0.496
CUP00350.1	hgdB	ERS852491_03979	ERS852491_03853	Protein of uncharacterised function (DUF523).	(R)-2-hydroxyglutaryl-CoA dehydratase subunit beta.	0.424
CUP18104.1	CUN92841.1	ERS852491_04478	ERS852491_00849	Fibronectin type III domain.	Uncharacterised protein.	0.675
CUP18104.1	CUN92893.1	ERS852491_04478	ERS852491_00851	Fibronectin type III domain.	Uncharacterised protein.	0.695

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.934

expected number of edges:

35

PPI enrichment p-value:

0.00985

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006071

Glycerol metabolic process

4 of 12

2.23

2.4

2.07e-05

GO:0006072

glycerol-3-phosphate metabolic process

3 of 4

2.58

2.24

6.99e-05

GO:0009401

Phosphoenolpyruvate-dependent sugar phosphotransferase system

3 of 8

2.28

1.95

0.00019

GO:0046168

glycerol-3-phosphate catabolic process

2 of 2

2.7

1.52

0.0017

GO:0006796

Phosphate-containing compound metabolic process

8 of 476

0.93

0.87

0.00011

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016901

Oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor

3 of 3

2.7

2.23

8.05e-05

GO:0016614

Oxidoreductase activity, acting on CH-OH group of donors

5 of 63

1.6

1.71

8.05e-05

GO:0004368

glycerol-3-phosphate dehydrogenase (quinone) activity

2 of 2

2.7

1.24

0.0056

GO:0004371

Glycerone kinase activity

2 of 3

2.53

1.18

0.0070

GO:0016301

Kinase activity

5 of 256

0.99

0.65

0.0126

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009331

glycerol-3-phosphate dehydrogenase complex

3 of 3

2.7

2.58

1.68e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3803

glycerol-3-phosphate metabolic process, and Glycerone kinase activity

7 of 8

2.65

6.67

7.88e-14

CL:2581

Phosphotransferase system

2 of 5

2.31

0.99

0.0152

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00564

Glycerophospholipid metabolism

4 of 41

1.69

0.00016

map02060

Phosphotransferase system (PTS)

2 of 6

2.23

1.22

0.0051

map00561

Glycerolipid metabolism

3 of 41

1.57

1.06

0.0051

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009331

glycerol-3-phosphate dehydrogenase complex

3 of 3

2.7

2.41

3.60e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0762

Sugar transport

2 of 5

2.31

1.13

0.0080

KW-0598

Phosphotransferase system

2 of 5

2.31

1.13

0.0080

KW-0418

Kinase

6 of 253

1.08

0.94

0.00078

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16901

C-terminal domain of alpha-glycerophosphate oxidase

2 of 2

2.7

1.01

0.0150

PF02896

PEP-utilising enzyme, PEP-binding domain

2 of 2

2.7

1.01

0.0150

PF00391

PEP-utilising enzyme, mobile domain

2 of 3

2.53

1.0

0.0150

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (16%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Fusion

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About