CUN85701.1 protein (Anaerobutyricum hallii) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

CUN85701.1

PAP2 superfamily. (227 aa)

Predicted Functional Partners:

CUO10589.1

0.891

gap

0.716

rfbB

0.692

pgsA_2

0.595

CUO90480.1

0.581

gltD_4

0.576

CUN85565.1

0.574

nqo9

0.559

CUO64939.1

0.559

CUO42947.1

0.546

Your Current Organism:

Anaerobutyricum hallii

NCBI taxonomy Id: 39488
Other names: A. hallii, ATCC 27751, DSM 3353, Eubacterium hallii, VPI B4-27

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUN85565.1	CUN85701.1	ERS852450_00739	ERS852450_00740	GTPase Era; Belongs to the EutP/PduV family.	PAP2 superfamily.	0.574
CUN85701.1	CUN85565.1	ERS852450_00740	ERS852450_00739	PAP2 superfamily.	GTPase Era; Belongs to the EutP/PduV family.	0.574
CUN85701.1	CUO10589.1	ERS852450_00740	ERS852450_01175	PAP2 superfamily.	Uncharacterised protein.	0.891
CUN85701.1	CUO42947.1	ERS852450_00740	ERS852450_01782	PAP2 superfamily.	Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family.	0.546
CUN85701.1	CUO64939.1	ERS852450_00740	ERS852450_02156	PAP2 superfamily.	Ferredoxin.	0.559
CUN85701.1	CUO90480.1	ERS852450_00740	ERS852450_02634	PAP2 superfamily.	Uncharacterised protein.	0.581
CUN85701.1	gap	ERS852450_00740	ERS852450_02864	PAP2 superfamily.	Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.	0.716
CUN85701.1	gltD_4	ERS852450_00740	ERS852450_01908	PAP2 superfamily.	Glutamate synthase [NADPH] small chain.	0.576
CUN85701.1	nqo9	ERS852450_00740	ERS852450_01909	PAP2 superfamily.	NADH-quinone oxidoreductase subunit 9.	0.559
CUN85701.1	pgsA_2	ERS852450_00740	ERS852450_01954	PAP2 superfamily.	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	0.595
CUN85701.1	rfbB	ERS852450_00740	ERS852450_02517	PAP2 superfamily.	dTDP-glucose 4%2C6-dehydratase.	0.692
CUO10589.1	CUN85701.1	ERS852450_01175	ERS852450_00740	Uncharacterised protein.	PAP2 superfamily.	0.891
CUO10589.1	CUO64939.1	ERS852450_01175	ERS852450_02156	Uncharacterised protein.	Ferredoxin.	0.652
CUO10589.1	CUO90480.1	ERS852450_01175	ERS852450_02634	Uncharacterised protein.	Uncharacterised protein.	0.650
CUO10589.1	gltD_4	ERS852450_01175	ERS852450_01908	Uncharacterised protein.	Glutamate synthase [NADPH] small chain.	0.679
CUO10589.1	nqo9	ERS852450_01175	ERS852450_01909	Uncharacterised protein.	NADH-quinone oxidoreductase subunit 9.	0.652
CUO10589.1	rfbB	ERS852450_01175	ERS852450_02517	Uncharacterised protein.	dTDP-glucose 4%2C6-dehydratase.	0.543
CUO42947.1	CUN85701.1	ERS852450_01782	ERS852450_00740	Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family.	PAP2 superfamily.	0.546
CUO64939.1	CUN85701.1	ERS852450_02156	ERS852450_00740	Ferredoxin.	PAP2 superfamily.	0.559
CUO64939.1	CUO10589.1	ERS852450_02156	ERS852450_01175	Ferredoxin.	Uncharacterised protein.	0.652

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.81

expected number of edges:

12

PPI enrichment p-value:

9.02e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042128

Nitrate assimilation

5 of 6

2.52

4.0

1.98e-08

GO:0043436

Oxoacid metabolic process

7 of 316

0.95

0.81

0.00071

GO:0044281

Small molecule metabolic process

8 of 611

0.72

0.54

0.0030

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008942

Nitrite reductase [NAD(P)H] activity

4 of 5

2.5

3.01

1.95e-06

GO:0050661

NADP binding

4 of 24

1.82

2.0

4.42e-05

GO:0020037

Heme binding

4 of 26

1.79

1.95

5.16e-05

GO:0051536

Iron-sulfur cluster binding

6 of 82

1.46

1.89

3.41e-06

GO:0050660

Flavin adenine dinucleotide binding

3 of 29

1.61

1.14

0.0037

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2600

Nitrate assimilation

6 of 7

2.53

5.25

4.60e-11

CL:2598

Mixed, incl. Nitrate assimilation, and Molybdopterin oxidoreductase

7 of 20

2.14

4.64

4.60e-11

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00910

Nitrogen metabolism

6 of 24

2.0

3.7

3.37e-09

map01120

Microbial metabolism in diverse environments

8 of 262

1.08

1.26

1.62e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0411

Iron-sulfur

5 of 42

1.68

2.06

1.10e-05

KW-0349

Heme

3 of 14

1.93

1.7

0.00035

KW-0004

4Fe-4S

4 of 36

1.65

1.67

0.00014

KW-0560

Oxidoreductase

6 of 196

1.09

1.04

0.00019

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01077

Nitrite and sulphite reductase 4Fe-4S domain

4 of 4

2.6

3.2

9.69e-07

PF04324

BFD-like [2Fe-2S] binding domain

3 of 3

2.6

2.22

7.60e-05

PF03460

Nitrite/Sulfite reductase ferredoxin-like half domain

3 of 3

2.6

2.22

7.60e-05

PF13738

Pyridine nucleotide-disulphide oxidoreductase

3 of 5

2.38

2.1

0.00011

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