node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACI55206.1 | fhs | Rleg2_1921 | Rleg2_2815 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: ret:RHE_CH02273 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rec:RHECIAT_CH0003236 formate-tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | 0.545 |
ACI55206.1 | glyA | Rleg2_1921 | Rleg2_1177 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: ret:RHE_CH02273 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.742 |
ACI55206.1 | glyA-2 | Rleg2_1921 | Rleg2_1626 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: ret:RHE_CH02273 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.742 |
ACI55206.1 | guaB | Rleg2_1921 | Rleg2_0432 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: ret:RHE_CH02273 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.828 |
ACI55206.1 | purD | Rleg2_1921 | Rleg2_0535 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: ret:RHE_CH02273 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | KEGG: rec:RHECIAT_CH0000977 phosphoribosylamine-glycine ligase protein; TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: phosphoribosylglycinamide synthetase; protein of unknown function DUF201; Belongs to the GARS family. | 0.950 |
ACI55206.1 | purE | Rleg2_1921 | Rleg2_3274 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: ret:RHE_CH02273 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.945 |
ACI55206.1 | purF | Rleg2_1921 | Rleg2_1042 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: ret:RHE_CH02273 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.967 |
ACI55206.1 | purH | Rleg2_1921 | Rleg2_3915 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: ret:RHE_CH02273 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | KEGG: rec:RHECIAT_CH0004399 IMP cyclohydrolase/phosphoribosylaminoimidazolecarboxamide formyltransferase protein; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.994 |
ACI55206.1 | purM | Rleg2_1921 | Rleg2_1095 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: ret:RHE_CH02273 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | KEGG: rec:RHECIAT_CH0001556 phosphoribosylformylglycinamidine cyclo-ligase protein; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein. | 0.918 |
ACI55206.1 | purN | Rleg2_1921 | Rleg2_1094 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: ret:RHE_CH02273 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.918 |
fhs | ACI55206.1 | Rleg2_2815 | Rleg2_1921 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rec:RHECIAT_CH0003236 formate-tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: ret:RHE_CH02273 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.545 |
fhs | glyA | Rleg2_2815 | Rleg2_1177 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rec:RHECIAT_CH0003236 formate-tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.957 |
fhs | glyA-2 | Rleg2_2815 | Rleg2_1626 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rec:RHECIAT_CH0003236 formate-tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.957 |
fhs | purD | Rleg2_2815 | Rleg2_0535 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rec:RHECIAT_CH0003236 formate-tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | KEGG: rec:RHECIAT_CH0000977 phosphoribosylamine-glycine ligase protein; TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: phosphoribosylglycinamide synthetase; protein of unknown function DUF201; Belongs to the GARS family. | 0.636 |
fhs | purE | Rleg2_2815 | Rleg2_3274 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rec:RHECIAT_CH0003236 formate-tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.680 |
fhs | purF | Rleg2_2815 | Rleg2_1042 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rec:RHECIAT_CH0003236 formate-tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.762 |
fhs | purH | Rleg2_2815 | Rleg2_3915 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rec:RHECIAT_CH0003236 formate-tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | KEGG: rec:RHECIAT_CH0004399 IMP cyclohydrolase/phosphoribosylaminoimidazolecarboxamide formyltransferase protein; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.989 |
fhs | purM | Rleg2_2815 | Rleg2_1095 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rec:RHECIAT_CH0003236 formate-tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | KEGG: rec:RHECIAT_CH0001556 phosphoribosylformylglycinamidine cyclo-ligase protein; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein. | 0.452 |
fhs | purN | Rleg2_2815 | Rleg2_1094 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rec:RHECIAT_CH0003236 formate-tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.963 |
glyA | ACI55206.1 | Rleg2_1177 | Rleg2_1921 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: ret:RHE_CH02273 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.742 |