STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ycgRType IV pilus assembly PilZ; Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility. (251 aa)    
Predicted Functional Partners:
Lcho_1012
PFAM: flagellar protein FliS; KEGG: mpt:Mpe_A2864 flagellar protein.
 
  
 0.888
Lcho_1000
PFAM: OmpA/MotB domain protein; KEGG: mpt:Mpe_A2873 chemotaxis signal transduction protein CheY.
 
 
 0.792
Lcho_1011
Flagellar hook-associated 2 domain protein; Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
  
  
 0.782
Lcho_1013
KEGG: mpt:Mpe_A2863 flagellar chaperone.
 
    0.781
Lcho_1023
PFAM: surface presentation of antigens (SPOA) protein; flagellar motor switch protein FliM; KEGG: mpt:Mpe_A0572 flagellar motor switch protein.
 
 
 0.746
Lcho_1001
KEGG: mpt:Mpe_A2872 chemotaxis signal transduction protein CheY.
 
   0.721
Lcho_0998
Chemotaxis phosphatase, CheZ; Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P).
 
    0.703
Lcho_2725
TIGRFAM: flagellar hook-associated protein FlgK; PFAM: protein of unknown function DUF1078 domain protein; KEGG: mpt:Mpe_A3064 flagellar hook-associated protein.
 
  
 0.684
Lcho_0352
KEGG: mpt:Mpe_A0286 hypothetical protein.
  
     0.650
Lcho_2735
TIGRFAM: flagella basal body P-ring formation protein FlgA; PFAM: SAF domain protein; KEGG: mpt:Mpe_A3074 flagellar basal body P-ring biosynthesis protein.
 
  
 0.649
Your Current Organism:
Leptothrix cholodnii
NCBI taxonomy Id: 395495
Other names: L. cholodnii SP-6, Leptothrix cholodnii SP-6, Leptothrix cholodnii str. SP-6, Leptothrix cholodnii strain SP-6
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.