node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Lcho_3137 | hisA | Lcho_3137 | Lcho_1591 | PFAM: histidine biosynthesis protein; KEGG: mpt:Mpe_A2622 HisA/HisF family protein, putative; Belongs to the HisA/HisF family. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mpt:Mpe_A0835 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.929 |
Lcho_3137 | hisF | Lcho_3137 | Lcho_1592 | PFAM: histidine biosynthesis protein; KEGG: mpt:Mpe_A2622 HisA/HisF family protein, putative; Belongs to the HisA/HisF family. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.918 |
Lcho_3137 | hisH | Lcho_3137 | Lcho_1590 | PFAM: histidine biosynthesis protein; KEGG: mpt:Mpe_A2622 HisA/HisF family protein, putative; Belongs to the HisA/HisF family. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.900 |
Lcho_3137 | hisI | Lcho_3137 | Lcho_1611 | PFAM: histidine biosynthesis protein; KEGG: mpt:Mpe_A2622 HisA/HisF family protein, putative; Belongs to the HisA/HisF family. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.900 |
hisA | Lcho_3137 | Lcho_1591 | Lcho_3137 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mpt:Mpe_A0835 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | PFAM: histidine biosynthesis protein; KEGG: mpt:Mpe_A2622 HisA/HisF family protein, putative; Belongs to the HisA/HisF family. | 0.929 |
hisA | hisB | Lcho_1591 | Lcho_1589 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mpt:Mpe_A0835 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mpt:Mpe_A0833 imidazoleglycerol-phosphate dehydratase. | 0.992 |
hisA | hisC | Lcho_1591 | Lcho_1588 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mpt:Mpe_A0835 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: mpt:Mpe_A0832 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.982 |
hisA | hisD | Lcho_1591 | Lcho_1587 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mpt:Mpe_A0835 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.995 |
hisA | hisE | Lcho_1591 | Lcho_1610 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mpt:Mpe_A0835 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: mpt:Mpe_A0838 phosphoribosyl-ATP pyrophosphatase. | 0.986 |
hisA | hisF | Lcho_1591 | Lcho_1592 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mpt:Mpe_A0835 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.998 |
hisA | hisG | Lcho_1591 | Lcho_1586 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mpt:Mpe_A0835 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.990 |
hisA | hisH | Lcho_1591 | Lcho_1590 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mpt:Mpe_A0835 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | Lcho_1591 | Lcho_1611 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mpt:Mpe_A0835 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | hisZ | Lcho_1591 | Lcho_2858 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mpt:Mpe_A0835 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | tRNA synthetase class II (G H P and S); Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.941 |
hisB | hisA | Lcho_1589 | Lcho_1591 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mpt:Mpe_A0833 imidazoleglycerol-phosphate dehydratase. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mpt:Mpe_A0835 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.992 |
hisB | hisC | Lcho_1589 | Lcho_1588 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mpt:Mpe_A0833 imidazoleglycerol-phosphate dehydratase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: mpt:Mpe_A0832 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | Lcho_1589 | Lcho_1587 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mpt:Mpe_A0833 imidazoleglycerol-phosphate dehydratase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisE | Lcho_1589 | Lcho_1610 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mpt:Mpe_A0833 imidazoleglycerol-phosphate dehydratase. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: mpt:Mpe_A0838 phosphoribosyl-ATP pyrophosphatase. | 0.985 |
hisB | hisF | Lcho_1589 | Lcho_1592 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mpt:Mpe_A0833 imidazoleglycerol-phosphate dehydratase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | Lcho_1589 | Lcho_1586 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mpt:Mpe_A0833 imidazoleglycerol-phosphate dehydratase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.993 |