STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Lcho_2008Putative signal transduction protein; PFAM: Metal-dependent hydrolase HDOD; KEGG: har:HEAR2840 hypothetical protein. (288 aa)    
Predicted Functional Partners:
Lcho_1054
Putative signal transduction protein; PFAM: Metal-dependent hydrolase HDOD; KEGG: rfr:Rfer_2728 serine/threonine protein kinase.
  
     0.719
Lcho_2578
PFAM: response regulator receiver; Tetratricopeptide TPR_4; Tetratricopeptide TPR_2 repeat protein; KEGG: rfr:Rfer_1420 response regulator receiver domain protein.
  
     0.632
Lcho_2016
KEGG: mpt:Mpe_A1552 hypothetical protein.
 
     0.604
Lcho_2009
Regulator of ribonuclease activity A; Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
       0.499
Lcho_3092
KEGG: dar:Daro_0889 hypothetical protein.
  
     0.491
Lcho_4242
PFAM: Metal-dependent hydrolase HDOD; KEGG: mpt:Mpe_A3409 hypothetical protein.
  
     0.470
Lcho_4069
PAS/PAC sensor hybrid histidine kinase; KEGG: azo:azo2482 putative hybrid sensor and regulator; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein.
 
 
 
 0.450
dsbD
Protein-disulfide reductase; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. Belongs to the thioredoxin family. DsbD subfamily.
       0.443
flgI
Flagellar P-ring protein; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
 
     0.442
Lcho_2909
KEGG: mms:mma_3355 type IV fimbrial biogenesis protein PilY1.
  
    0.442
Your Current Organism:
Leptothrix cholodnii
NCBI taxonomy Id: 395495
Other names: L. cholodnii SP-6, Leptothrix cholodnii SP-6, Leptothrix cholodnii str. SP-6, Leptothrix cholodnii strain SP-6
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