node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Lcho_3013 | Lcho_3214 | Lcho_3013 | Lcho_3214 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: rpa:RPA0955 putative 5'-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | PFAM: 5'-Nucleotidase domain protein; KEGG: sde:Sde_0580 alkaline phosphatase; Belongs to the 5'-nucleotidase family. | 0.915 |
Lcho_3013 | gmk | Lcho_3013 | Lcho_0729 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: rpa:RPA0955 putative 5'-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.901 |
Lcho_3013 | guaA | Lcho_3013 | Lcho_2063 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: rpa:RPA0955 putative 5'-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.916 |
Lcho_3013 | guaB | Lcho_3013 | Lcho_2061 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: rpa:RPA0955 putative 5'-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.906 |
Lcho_3013 | guaC | Lcho_3013 | Lcho_2764 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: rpa:RPA0955 putative 5'-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.906 |
Lcho_3013 | purA | Lcho_3013 | Lcho_2857 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: rpa:RPA0955 putative 5'-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.910 |
Lcho_3013 | purH | Lcho_3013 | Lcho_0532 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: rpa:RPA0955 putative 5'-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | KEGG: mpt:Mpe_A0485 IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.906 |
Lcho_3013 | surE | Lcho_3013 | Lcho_1922 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: rpa:RPA0955 putative 5'-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.909 |
Lcho_3214 | Lcho_3013 | Lcho_3214 | Lcho_3013 | PFAM: 5'-Nucleotidase domain protein; KEGG: sde:Sde_0580 alkaline phosphatase; Belongs to the 5'-nucleotidase family. | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: rpa:RPA0955 putative 5'-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | 0.915 |
Lcho_3214 | gmk | Lcho_3214 | Lcho_0729 | PFAM: 5'-Nucleotidase domain protein; KEGG: sde:Sde_0580 alkaline phosphatase; Belongs to the 5'-nucleotidase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.901 |
Lcho_3214 | guaA | Lcho_3214 | Lcho_2063 | PFAM: 5'-Nucleotidase domain protein; KEGG: sde:Sde_0580 alkaline phosphatase; Belongs to the 5'-nucleotidase family. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.916 |
Lcho_3214 | guaB | Lcho_3214 | Lcho_2061 | PFAM: 5'-Nucleotidase domain protein; KEGG: sde:Sde_0580 alkaline phosphatase; Belongs to the 5'-nucleotidase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.906 |
Lcho_3214 | guaC | Lcho_3214 | Lcho_2764 | PFAM: 5'-Nucleotidase domain protein; KEGG: sde:Sde_0580 alkaline phosphatase; Belongs to the 5'-nucleotidase family. | Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.906 |
Lcho_3214 | purA | Lcho_3214 | Lcho_2857 | PFAM: 5'-Nucleotidase domain protein; KEGG: sde:Sde_0580 alkaline phosphatase; Belongs to the 5'-nucleotidase family. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.910 |
Lcho_3214 | purH | Lcho_3214 | Lcho_0532 | PFAM: 5'-Nucleotidase domain protein; KEGG: sde:Sde_0580 alkaline phosphatase; Belongs to the 5'-nucleotidase family. | KEGG: mpt:Mpe_A0485 IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.906 |
Lcho_3214 | surE | Lcho_3214 | Lcho_1922 | PFAM: 5'-Nucleotidase domain protein; KEGG: sde:Sde_0580 alkaline phosphatase; Belongs to the 5'-nucleotidase family. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.909 |
gmk | Lcho_3013 | Lcho_0729 | Lcho_3013 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: rpa:RPA0955 putative 5'-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | 0.901 |
gmk | Lcho_3214 | Lcho_0729 | Lcho_3214 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | PFAM: 5'-Nucleotidase domain protein; KEGG: sde:Sde_0580 alkaline phosphatase; Belongs to the 5'-nucleotidase family. | 0.901 |
gmk | guaA | Lcho_0729 | Lcho_2063 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.972 |
gmk | guaB | Lcho_0729 | Lcho_2061 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.611 |