STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Lcho_2805TIGRFAM: thioredoxin; PFAM: Thioredoxin domain; KEGG: mpt:Mpe_A1283 thioredoxin 1; Belongs to the thioredoxin family. (109 aa)    
Predicted Functional Partners:
Lcho_0754
KEGG: mpt:Mpe_A1118 thioredoxin reductase; TIGRFAM: thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase.
 
 0.974
Lcho_2791
PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: dac:Daci_4658 FAD-dependent pyridine nucleotide-disulphide oxidoreductase.
  
 
 0.718
Lcho_1553
PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: ade:Adeh_2667 FAD-dependent pyridine nucleotide-disulphide oxidoreductase.
  
 
 0.692
Lcho_1648
TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: ajs:Ajs_2096 dihydrolipoamide dehydrogenase.
  
 
 0.687
rho
Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template.
  
  
 0.658
Lcho_2786
Adenylylsulfate reductase, thioredoxin dependent; Reduction of activated sulfate into sulfite.
    
 
 0.639
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
 
  
 0.624
fur
Ferric uptake regulator, Fur family; PFAM: ferric-uptake regulator; KEGG: mpt:Mpe_A0223 transcriptional regulator; Belongs to the Fur family.
  
 
 0.576
fur-2
Ferric uptake regulator, Fur family; PFAM: ferric-uptake regulator; KEGG: dac:Daci_4458 ferric uptake regulator, Fur family; Belongs to the Fur family.
  
 
 0.576
hslU
Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
  
 
 0.559
Your Current Organism:
Leptothrix cholodnii
NCBI taxonomy Id: 395495
Other names: L. cholodnii SP-6, Leptothrix cholodnii SP-6, Leptothrix cholodnii str. SP-6, Leptothrix cholodnii strain SP-6
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