STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Lcho_3383PFAM: ThiJ/PfpI domain protein; KEGG: aav:Aave_1967 ThiJ/PfpI domain protein. (225 aa)    
Predicted Functional Partners:
Lcho_3382
Amidohydrolase; KEGG: mpt:Mpe_A3092 hippurate hydrolase; TIGRFAM: amidohydrolase; PFAM: peptidase M20; peptidase dimerisation domain protein.
       0.773
rpoD
RNA polymerase, sigma 70 subunit, RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
   
 
 0.686
Lcho_3381
PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: mpt:Mpe_A3090 conserved hypothetical oxidoreductase protein; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
       0.561
Lcho_3380
KEGG: mpt:Mpe_A3087 putative zinc protease protein.
       0.543
rpoH
RNA polymerase, sigma 32 subunit, RpoH; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.
   
 
 0.453
lexA
Transcriptional repressor, LexA family; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
   
 
 0.452
Lcho_1107
PFAM: helix-turn-helix- domain containing protein AraC type; HhH-GPD family protein; Ada metal-binding domain protein; AlkA domain protein; KEGG: spe:Spro_3547 transcriptional regulator, AraC family.
  
  
 0.450
Lcho_2946
KEGG: xcb:XC_2829 hypothetical protein.
   
    0.426
Lcho_3182
Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: vei:Veis_3165 helix-turn-helix-domain containing protein, AraC type.
 
 
 0.403
Your Current Organism:
Leptothrix cholodnii
NCBI taxonomy Id: 395495
Other names: L. cholodnii SP-6, Leptothrix cholodnii SP-6, Leptothrix cholodnii str. SP-6, Leptothrix cholodnii strain SP-6
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.