| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Bind_0267 | Bind_1572 | Bind_0267 | Bind_1572 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | TIGRFAM: sulfate ABC transporter, periplasmic sulfate-binding protein; PFAM: extracellular solute-binding protein family 1; KEGG: rru:Rru_A3400 thiosulphate-binding protein. | 0.447 |
| Bind_0267 | Bind_1690 | Bind_0267 | Bind_1690 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | TIGRFAM: sulfate ABC transporter, periplasmic sulfate-binding protein; PFAM: extracellular solute-binding protein family 1; KEGG: nha:Nham_3560 thiosulphate-binding protein. | 0.447 |
| Bind_0267 | Bind_2258 | Bind_0267 | Bind_2258 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | TIGRFAM: sulfate ABC transporter, inner membrane subunit; sulfate ABC transporter, inner membrane subunit CysW; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: rru:Rru_A3402 sulfate ABC transporter, permease protein CysW. | 0.650 |
| Bind_0267 | Bind_2259 | Bind_0267 | Bind_2259 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Sulfate ABC transporter, inner membrane subunit CysT; Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. | 0.457 |
| Bind_0267 | Bind_2261 | Bind_0267 | Bind_2261 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | PFAM: nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein; nitrite and sulphite reductase 4Fe-4S region; KEGG: oan:Oant_0190 sulfite reductase (ferredoxin). | 0.975 |
| Bind_0267 | cysA | Bind_0267 | Bind_2257 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Sulfate ABC transporter, ATPase subunit; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. | 0.598 |
| Bind_0267 | cysC | Bind_0267 | Bind_0070 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Sulfate adenylyltransferase, large subunit; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.968 |
| Bind_0267 | cysD | Bind_0267 | Bind_0071 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | TIGRFAM: sulfate adenylyltransferase, small subunit; PFAM: phosphoadenosine phosphosulfate reductase; KEGG: bur:Bcep18194_A5495 sulfate adenylyltransferase subunit 2. | 0.949 |
| Bind_0267 | cysH | Bind_0267 | Bind_2262 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | 0.973 |
| Bind_0267 | cysQ | Bind_0267 | Bind_1020 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. | 0.624 |
| Bind_1572 | Bind_0267 | Bind_1572 | Bind_0267 | TIGRFAM: sulfate ABC transporter, periplasmic sulfate-binding protein; PFAM: extracellular solute-binding protein family 1; KEGG: rru:Rru_A3400 thiosulphate-binding protein. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.447 |
| Bind_1572 | Bind_1690 | Bind_1572 | Bind_1690 | TIGRFAM: sulfate ABC transporter, periplasmic sulfate-binding protein; PFAM: extracellular solute-binding protein family 1; KEGG: rru:Rru_A3400 thiosulphate-binding protein. | TIGRFAM: sulfate ABC transporter, periplasmic sulfate-binding protein; PFAM: extracellular solute-binding protein family 1; KEGG: nha:Nham_3560 thiosulphate-binding protein. | 0.908 |
| Bind_1572 | Bind_2258 | Bind_1572 | Bind_2258 | TIGRFAM: sulfate ABC transporter, periplasmic sulfate-binding protein; PFAM: extracellular solute-binding protein family 1; KEGG: rru:Rru_A3400 thiosulphate-binding protein. | TIGRFAM: sulfate ABC transporter, inner membrane subunit; sulfate ABC transporter, inner membrane subunit CysW; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: rru:Rru_A3402 sulfate ABC transporter, permease protein CysW. | 0.995 |
| Bind_1572 | Bind_2259 | Bind_1572 | Bind_2259 | TIGRFAM: sulfate ABC transporter, periplasmic sulfate-binding protein; PFAM: extracellular solute-binding protein family 1; KEGG: rru:Rru_A3400 thiosulphate-binding protein. | Sulfate ABC transporter, inner membrane subunit CysT; Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. | 0.995 |
| Bind_1572 | Bind_2261 | Bind_1572 | Bind_2261 | TIGRFAM: sulfate ABC transporter, periplasmic sulfate-binding protein; PFAM: extracellular solute-binding protein family 1; KEGG: rru:Rru_A3400 thiosulphate-binding protein. | PFAM: nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein; nitrite and sulphite reductase 4Fe-4S region; KEGG: oan:Oant_0190 sulfite reductase (ferredoxin). | 0.414 |
| Bind_1572 | cysA | Bind_1572 | Bind_2257 | TIGRFAM: sulfate ABC transporter, periplasmic sulfate-binding protein; PFAM: extracellular solute-binding protein family 1; KEGG: rru:Rru_A3400 thiosulphate-binding protein. | Sulfate ABC transporter, ATPase subunit; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. | 0.994 |
| Bind_1572 | cysC | Bind_1572 | Bind_0070 | TIGRFAM: sulfate ABC transporter, periplasmic sulfate-binding protein; PFAM: extracellular solute-binding protein family 1; KEGG: rru:Rru_A3400 thiosulphate-binding protein. | Sulfate adenylyltransferase, large subunit; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.998 |
| Bind_1572 | cysD | Bind_1572 | Bind_0071 | TIGRFAM: sulfate ABC transporter, periplasmic sulfate-binding protein; PFAM: extracellular solute-binding protein family 1; KEGG: rru:Rru_A3400 thiosulphate-binding protein. | TIGRFAM: sulfate adenylyltransferase, small subunit; PFAM: phosphoadenosine phosphosulfate reductase; KEGG: bur:Bcep18194_A5495 sulfate adenylyltransferase subunit 2. | 0.979 |
| Bind_1572 | cysH | Bind_1572 | Bind_2262 | TIGRFAM: sulfate ABC transporter, periplasmic sulfate-binding protein; PFAM: extracellular solute-binding protein family 1; KEGG: rru:Rru_A3400 thiosulphate-binding protein. | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | 0.663 |
| Bind_1690 | Bind_0267 | Bind_1690 | Bind_0267 | TIGRFAM: sulfate ABC transporter, periplasmic sulfate-binding protein; PFAM: extracellular solute-binding protein family 1; KEGG: nha:Nham_3560 thiosulphate-binding protein. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.447 |