| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Bind_0041 | Bind_0175 | Bind_0041 | Bind_0175 | PFAM: Aldehyde Dehydrogenase_; KEGG: cak:Caul_4341 aldehyde dehydrogenase_; Belongs to the aldehyde dehydrogenase family. | TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase_; KEGG: xau:Xaut_3248 methylmalonate-semialdehyde dehydrogenase. | 0.919 |
| Bind_0041 | Bind_0613 | Bind_0041 | Bind_0613 | PFAM: Aldehyde Dehydrogenase_; KEGG: cak:Caul_4341 aldehyde dehydrogenase_; Belongs to the aldehyde dehydrogenase family. | PFAM: AMP-dependent synthetase and ligase; KEGG: dol:Dole_1499 AMP-dependent synthetase and ligase. | 0.859 |
| Bind_0041 | Bind_0615 | Bind_0041 | Bind_0615 | PFAM: Aldehyde Dehydrogenase_; KEGG: cak:Caul_4341 aldehyde dehydrogenase_; Belongs to the aldehyde dehydrogenase family. | KEGG: rle:pRL110406 putative 3-hydroxyisobutyrate dehydrogenase; TIGRFAM: 3-hydroxyisobutyrate dehydrogenase; PFAM: NADP oxidoreductase coenzyme F420-dependent; 6-phosphogluconate dehydrogenase NAD-binding; Belongs to the HIBADH-related family. | 0.911 |
| Bind_0041 | Bind_1242 | Bind_0041 | Bind_1242 | PFAM: Aldehyde Dehydrogenase_; KEGG: cak:Caul_4341 aldehyde dehydrogenase_; Belongs to the aldehyde dehydrogenase family. | PFAM: aminotransferase class-III; KEGG: rpe:RPE_0915 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.903 |
| Bind_0041 | Bind_1317 | Bind_0041 | Bind_1317 | PFAM: Aldehyde Dehydrogenase_; KEGG: cak:Caul_4341 aldehyde dehydrogenase_; Belongs to the aldehyde dehydrogenase family. | PFAM: carboxyl transferase; KEGG: ret:RHE_CH02232 propionyl-CoA carboxylase beta chain protein. | 0.822 |
| Bind_0041 | Bind_1788 | Bind_0041 | Bind_1788 | PFAM: Aldehyde Dehydrogenase_; KEGG: cak:Caul_4341 aldehyde dehydrogenase_; Belongs to the aldehyde dehydrogenase family. | 3-hydroxyisobutyrate dehydrogenase; PFAM: NADP oxidoreductase coenzyme F420-dependent; 6-phosphogluconate dehydrogenase NAD-binding; KEGG: rpb:RPB_3394 3-hydroxyisobutyrate dehydrogenase. | 0.909 |
| Bind_0041 | Bind_2202 | Bind_0041 | Bind_2202 | PFAM: Aldehyde Dehydrogenase_; KEGG: cak:Caul_4341 aldehyde dehydrogenase_; Belongs to the aldehyde dehydrogenase family. | PFAM: phosphate acetyl/butaryl transferase; MaoC domain protein dehydratase; KEGG: azc:AZC_2420 phosphate acetyl/butyryltransferase family protein. | 0.836 |
| Bind_0041 | acsA | Bind_0041 | Bind_0053 | PFAM: Aldehyde Dehydrogenase_; KEGG: cak:Caul_4341 aldehyde dehydrogenase_; Belongs to the aldehyde dehydrogenase family. | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.929 |
| Bind_0175 | Bind_0041 | Bind_0175 | Bind_0041 | TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase_; KEGG: xau:Xaut_3248 methylmalonate-semialdehyde dehydrogenase. | PFAM: Aldehyde Dehydrogenase_; KEGG: cak:Caul_4341 aldehyde dehydrogenase_; Belongs to the aldehyde dehydrogenase family. | 0.919 |
| Bind_0175 | Bind_0427 | Bind_0175 | Bind_0427 | TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase_; KEGG: xau:Xaut_3248 methylmalonate-semialdehyde dehydrogenase. | KEGG: mex:Mext_3469 acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.911 |
| Bind_0175 | Bind_0613 | Bind_0175 | Bind_0613 | TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase_; KEGG: xau:Xaut_3248 methylmalonate-semialdehyde dehydrogenase. | PFAM: AMP-dependent synthetase and ligase; KEGG: dol:Dole_1499 AMP-dependent synthetase and ligase. | 0.929 |
| Bind_0175 | Bind_0615 | Bind_0175 | Bind_0615 | TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase_; KEGG: xau:Xaut_3248 methylmalonate-semialdehyde dehydrogenase. | KEGG: rle:pRL110406 putative 3-hydroxyisobutyrate dehydrogenase; TIGRFAM: 3-hydroxyisobutyrate dehydrogenase; PFAM: NADP oxidoreductase coenzyme F420-dependent; 6-phosphogluconate dehydrogenase NAD-binding; Belongs to the HIBADH-related family. | 0.926 |
| Bind_0175 | Bind_1242 | Bind_0175 | Bind_1242 | TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase_; KEGG: xau:Xaut_3248 methylmalonate-semialdehyde dehydrogenase. | PFAM: aminotransferase class-III; KEGG: rpe:RPE_0915 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.932 |
| Bind_0175 | Bind_1317 | Bind_0175 | Bind_1317 | TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase_; KEGG: xau:Xaut_3248 methylmalonate-semialdehyde dehydrogenase. | PFAM: carboxyl transferase; KEGG: ret:RHE_CH02232 propionyl-CoA carboxylase beta chain protein. | 0.911 |
| Bind_0175 | Bind_1756 | Bind_0175 | Bind_1756 | TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase_; KEGG: xau:Xaut_3248 methylmalonate-semialdehyde dehydrogenase. | KEGG: rru:Rru_A1310 acetyl-CoA C-acyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.911 |
| Bind_0175 | Bind_1788 | Bind_0175 | Bind_1788 | TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase_; KEGG: xau:Xaut_3248 methylmalonate-semialdehyde dehydrogenase. | 3-hydroxyisobutyrate dehydrogenase; PFAM: NADP oxidoreductase coenzyme F420-dependent; 6-phosphogluconate dehydrogenase NAD-binding; KEGG: rpb:RPB_3394 3-hydroxyisobutyrate dehydrogenase. | 0.921 |
| Bind_0175 | Bind_2202 | Bind_0175 | Bind_2202 | TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase_; KEGG: xau:Xaut_3248 methylmalonate-semialdehyde dehydrogenase. | PFAM: phosphate acetyl/butaryl transferase; MaoC domain protein dehydratase; KEGG: azc:AZC_2420 phosphate acetyl/butyryltransferase family protein. | 0.918 |
| Bind_0175 | acsA | Bind_0175 | Bind_0053 | TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase_; KEGG: xau:Xaut_3248 methylmalonate-semialdehyde dehydrogenase. | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.929 |
| Bind_0427 | Bind_0175 | Bind_0427 | Bind_0175 | KEGG: mex:Mext_3469 acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase_; KEGG: xau:Xaut_3248 methylmalonate-semialdehyde dehydrogenase. | 0.911 |
| Bind_0427 | Bind_0613 | Bind_0427 | Bind_0613 | KEGG: mex:Mext_3469 acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | PFAM: AMP-dependent synthetase and ligase; KEGG: dol:Dole_1499 AMP-dependent synthetase and ligase. | 0.415 |