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Bind_0267uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (521 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.994
Bind_2261
PFAM: nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein; nitrite and sulphite reductase 4Fe-4S region; KEGG: oan:Oant_0190 sulfite reductase (ferredoxin).
 
  
 0.975
cysH
Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily.
 
  
 0.973
cysC
Sulfate adenylyltransferase, large subunit; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
  
  
 0.968
Bind_0008
Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
 
 0.966
Bind_3510
TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: mex:Mext_1436 precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family.
 
  
 0.964
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
    
 0.960
Bind_3508
TIGRFAM: precorrin-3B synthase; PFAM: nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein; KEGG: bbt:BBta_3145 putative precorrin-3B synthase (CobG).
  
  
 0.950
cysD
TIGRFAM: sulfate adenylyltransferase, small subunit; PFAM: phosphoadenosine phosphosulfate reductase; KEGG: bur:Bcep18194_A5495 sulfate adenylyltransferase subunit 2.
 
  
 0.949
Bind_1208
Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mex:Mext_4238 porphobilinogen synthase; Belongs to the ALAD family.
 
  
 0.925
Your Current Organism:
Beijerinckia indica
NCBI taxonomy Id: 395963
Other names: B. indica subsp. indica ATCC 9039, Beijerinckia indica subsp. indica ATCC 9039, Beijerinckia indica subsp. indica str. ATCC 9039, Beijerinckia indica subsp. indica strain ATCC 9039
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