| node1 | node2 | node1 annotation | node2 annotation | score |
| Bind_0267 | Bind_0566 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Rieske [2Fe-2S] domain protein; KEGG: bam:Bamb_5661 FAD-dependent pyridine nucleotide-disulphide oxidoreductase. | 0.918 |
| Bind_0267 | Bind_1715 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | PFAM: molybdopterin biosynthesis MoaE protein; KEGG: mlo:mlr7915 molybdopterin converting factor, subunit 2. | 0.567 |
| Bind_0267 | Bind_1968 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | PFAM: response regulator receiver; ANTAR domain protein; KEGG: pat:Patl_2529 response regulator receiver and ANTAR domain protein. | 0.588 |
| Bind_0267 | Bind_1969 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; FAD-binding domain protein; molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; flavodoxin/nitric oxide synthase; KEGG: mfa:Mfla_0317 molybdopterin oxidoreductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. | 0.878 |
| Bind_0267 | Bind_1970 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | TIGRFAM: nitrite reductase [NAD(P)H], large subunit; nitrite reductase [NAD(P)H], small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein; nitrite and sulphite reductase 4Fe-4S region; BFD domain protein [2Fe-2S]-binding domain protein; KEGG: ppf:Pput_4015 nitrite reductase (NAD(P)H), large subunit. | 0.923 |
| Bind_0267 | Bind_1971 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | PFAM: major facilitator superfamily MFS_1; KEGG: eba:ebA1213 nitrate transporter. | 0.633 |
| Bind_0566 | Bind_0267 | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Rieske [2Fe-2S] domain protein; KEGG: bam:Bamb_5661 FAD-dependent pyridine nucleotide-disulphide oxidoreductase. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.918 |
| Bind_0566 | Bind_1968 | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Rieske [2Fe-2S] domain protein; KEGG: bam:Bamb_5661 FAD-dependent pyridine nucleotide-disulphide oxidoreductase. | PFAM: response regulator receiver; ANTAR domain protein; KEGG: pat:Patl_2529 response regulator receiver and ANTAR domain protein. | 0.513 |
| Bind_0566 | Bind_1969 | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Rieske [2Fe-2S] domain protein; KEGG: bam:Bamb_5661 FAD-dependent pyridine nucleotide-disulphide oxidoreductase. | PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; FAD-binding domain protein; molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; flavodoxin/nitric oxide synthase; KEGG: mfa:Mfla_0317 molybdopterin oxidoreductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. | 0.785 |
| Bind_0566 | Bind_1970 | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Rieske [2Fe-2S] domain protein; KEGG: bam:Bamb_5661 FAD-dependent pyridine nucleotide-disulphide oxidoreductase. | TIGRFAM: nitrite reductase [NAD(P)H], large subunit; nitrite reductase [NAD(P)H], small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein; nitrite and sulphite reductase 4Fe-4S region; BFD domain protein [2Fe-2S]-binding domain protein; KEGG: ppf:Pput_4015 nitrite reductase (NAD(P)H), large subunit. | 0.963 |
| Bind_0566 | Bind_1971 | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Rieske [2Fe-2S] domain protein; KEGG: bam:Bamb_5661 FAD-dependent pyridine nucleotide-disulphide oxidoreductase. | PFAM: major facilitator superfamily MFS_1; KEGG: eba:ebA1213 nitrate transporter. | 0.483 |
| Bind_0566 | Bind_1972 | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Rieske [2Fe-2S] domain protein; KEGG: bam:Bamb_5661 FAD-dependent pyridine nucleotide-disulphide oxidoreductase. | PFAM: globin; oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: gdi:GDI0493 putative flavohemoprotein; Belongs to the globin family. | 0.771 |
| Bind_1715 | Bind_0267 | PFAM: molybdopterin biosynthesis MoaE protein; KEGG: mlo:mlr7915 molybdopterin converting factor, subunit 2. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.567 |
| Bind_1715 | Bind_1969 | PFAM: molybdopterin biosynthesis MoaE protein; KEGG: mlo:mlr7915 molybdopterin converting factor, subunit 2. | PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; FAD-binding domain protein; molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; flavodoxin/nitric oxide synthase; KEGG: mfa:Mfla_0317 molybdopterin oxidoreductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. | 0.476 |
| Bind_1715 | Bind_1971 | PFAM: molybdopterin biosynthesis MoaE protein; KEGG: mlo:mlr7915 molybdopterin converting factor, subunit 2. | PFAM: major facilitator superfamily MFS_1; KEGG: eba:ebA1213 nitrate transporter. | 0.451 |
| Bind_1749 | Bind_1970 | PFAM: 2-nitropropane dioxygenase NPD; KEGG: azc:AZC_0931 putative 2-nitropropane dioxygenase. | TIGRFAM: nitrite reductase [NAD(P)H], large subunit; nitrite reductase [NAD(P)H], small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein; nitrite and sulphite reductase 4Fe-4S region; BFD domain protein [2Fe-2S]-binding domain protein; KEGG: ppf:Pput_4015 nitrite reductase (NAD(P)H), large subunit. | 0.900 |
| Bind_1749 | Bind_1971 | PFAM: 2-nitropropane dioxygenase NPD; KEGG: azc:AZC_0931 putative 2-nitropropane dioxygenase. | PFAM: major facilitator superfamily MFS_1; KEGG: eba:ebA1213 nitrate transporter. | 0.910 |
| Bind_1749 | Bind_2091 | PFAM: 2-nitropropane dioxygenase NPD; KEGG: azc:AZC_0931 putative 2-nitropropane dioxygenase. | PFAM: 2-nitropropane dioxygenase NPD; KEGG: ret:RHE_PF00539 probable dioxygenase protein. | 0.925 |
| Bind_1967 | Bind_1968 | ABC-type nitrate/sulfonate/bicarbonate transport systems periplasmic component-like protein; KEGG: cyb:CYB_0037 nitrate ABC transporter, ATP-binding protein NtrC. | PFAM: response regulator receiver; ANTAR domain protein; KEGG: pat:Patl_2529 response regulator receiver and ANTAR domain protein. | 0.958 |
| Bind_1967 | Bind_1969 | ABC-type nitrate/sulfonate/bicarbonate transport systems periplasmic component-like protein; KEGG: cyb:CYB_0037 nitrate ABC transporter, ATP-binding protein NtrC. | PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; FAD-binding domain protein; molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; flavodoxin/nitric oxide synthase; KEGG: mfa:Mfla_0317 molybdopterin oxidoreductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. | 0.937 |