| node1 | node2 | node1 annotation | node2 annotation | score |
| Bind_0267 | Bind_1969 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; FAD-binding domain protein; molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; flavodoxin/nitric oxide synthase; KEGG: mfa:Mfla_0317 molybdopterin oxidoreductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. | 0.878 |
| Bind_0267 | Bind_2488 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: ret:RHE_CH02643 ferredoxin reductase protein. | 0.673 |
| Bind_0267 | Bind_2490 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | TIGRFAM: Rieske [2Fe-2S] domain protein, MocE subfamily; PFAM: Rieske [2Fe-2S] domain protein; KEGG: sme:SMa2053 MocE-like protein. | 0.764 |
| Bind_0267 | Bind_2768 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | TIGRFAM: Rieske [2Fe-2S] domain protein, MocE subfamily; PFAM: Rieske [2Fe-2S] domain protein; KEGG: smd:Smed_5006 Rieske (2Fe-2S) domain protein, MocE subfamily. | 0.764 |
| Bind_0267 | Bind_2850 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: ccr:CC_3525 ferredoxin reductase. | 0.683 |
| Bind_0539 | Bind_1969 | PFAM: ferredoxin; KEGG: mlo:msl0793 ferredoxin. | PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; FAD-binding domain protein; molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; flavodoxin/nitric oxide synthase; KEGG: mfa:Mfla_0317 molybdopterin oxidoreductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. | 0.496 |
| Bind_0539 | Bind_2488 | PFAM: ferredoxin; KEGG: mlo:msl0793 ferredoxin. | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: ret:RHE_CH02643 ferredoxin reductase protein. | 0.589 |
| Bind_0539 | Bind_2850 | PFAM: ferredoxin; KEGG: mlo:msl0793 ferredoxin. | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: ccr:CC_3525 ferredoxin reductase. | 0.717 |
| Bind_0990 | Bind_1969 | TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: ferredoxin; 4Fe-4S ferredoxin iron-sulfur binding domain protein; molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: mex:Mext_4406 formate dehydrogenase, alpha subunit. | PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; FAD-binding domain protein; molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; flavodoxin/nitric oxide synthase; KEGG: mfa:Mfla_0317 molybdopterin oxidoreductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. | 0.842 |
| Bind_0990 | Bind_1972 | TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: ferredoxin; 4Fe-4S ferredoxin iron-sulfur binding domain protein; molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: mex:Mext_4406 formate dehydrogenase, alpha subunit. | PFAM: globin; oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: gdi:GDI0493 putative flavohemoprotein; Belongs to the globin family. | 0.408 |
| Bind_0990 | Bind_2488 | TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: ferredoxin; 4Fe-4S ferredoxin iron-sulfur binding domain protein; molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: mex:Mext_4406 formate dehydrogenase, alpha subunit. | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: ret:RHE_CH02643 ferredoxin reductase protein. | 0.807 |
| Bind_0990 | Bind_2850 | TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: ferredoxin; 4Fe-4S ferredoxin iron-sulfur binding domain protein; molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: mex:Mext_4406 formate dehydrogenase, alpha subunit. | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: ccr:CC_3525 ferredoxin reductase. | 0.863 |
| Bind_1157 | Bind_1969 | PFAM: Rubredoxin-type Fe(Cys)4 protein; KEGG: xau:Xaut_2180 rubredoxin-type Fe(Cys)4 protein. | PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; FAD-binding domain protein; molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; flavodoxin/nitric oxide synthase; KEGG: mfa:Mfla_0317 molybdopterin oxidoreductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. | 0.437 |
| Bind_1157 | Bind_1972 | PFAM: Rubredoxin-type Fe(Cys)4 protein; KEGG: xau:Xaut_2180 rubredoxin-type Fe(Cys)4 protein. | PFAM: globin; oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: gdi:GDI0493 putative flavohemoprotein; Belongs to the globin family. | 0.427 |
| Bind_1157 | Bind_2488 | PFAM: Rubredoxin-type Fe(Cys)4 protein; KEGG: xau:Xaut_2180 rubredoxin-type Fe(Cys)4 protein. | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: ret:RHE_CH02643 ferredoxin reductase protein. | 0.775 |
| Bind_1157 | Bind_2850 | PFAM: Rubredoxin-type Fe(Cys)4 protein; KEGG: xau:Xaut_2180 rubredoxin-type Fe(Cys)4 protein. | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: ccr:CC_3525 ferredoxin reductase. | 0.775 |
| Bind_1969 | Bind_0267 | PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; FAD-binding domain protein; molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; flavodoxin/nitric oxide synthase; KEGG: mfa:Mfla_0317 molybdopterin oxidoreductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.878 |
| Bind_1969 | Bind_0539 | PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; FAD-binding domain protein; molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; flavodoxin/nitric oxide synthase; KEGG: mfa:Mfla_0317 molybdopterin oxidoreductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. | PFAM: ferredoxin; KEGG: mlo:msl0793 ferredoxin. | 0.496 |
| Bind_1969 | Bind_0990 | PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; FAD-binding domain protein; molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; flavodoxin/nitric oxide synthase; KEGG: mfa:Mfla_0317 molybdopterin oxidoreductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. | TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: ferredoxin; 4Fe-4S ferredoxin iron-sulfur binding domain protein; molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: mex:Mext_4406 formate dehydrogenase, alpha subunit. | 0.842 |
| Bind_1969 | Bind_1157 | PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; FAD-binding domain protein; molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; flavodoxin/nitric oxide synthase; KEGG: mfa:Mfla_0317 molybdopterin oxidoreductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. | PFAM: Rubredoxin-type Fe(Cys)4 protein; KEGG: xau:Xaut_2180 rubredoxin-type Fe(Cys)4 protein. | 0.437 |