Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Bind_2858KEGG: reh:H16_A3602 pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family. (477 aa)    
Predicted Functional Partners:
eno
Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
 
 0.980
Bind_2063
PFAM: phosphate acetyl/butaryl transferase; malic protein domain protein; malic protein NAD-binding; KEGG: mex:Mext_0827 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), phosphate acetyltransferase.
  
 0.959
pgi
PFAM: phosphoglucose isomerase (PGI); KEGG: smd:Smed_0109 glucose-6-phosphate isomerase; Belongs to the GPI family.
  
 0.943
Bind_1506
Transketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
  
 
 0.937
Bind_2859
PFAM: Aldehyde Dehydrogenase_; KEGG: bmu:Bmul_5161 aldehyde dehydrogenase.
  
 0.927
Bind_1529
Transketolase central region; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 
 0.918
Bind_3389
PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: gdi:GDI0172 pyruvate decarboxylase.
   
 0.915
ppc
Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family.
     
 0.911
ndk
Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
    
 0.910
pdhA
Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 
 0.907
Your Current Organism:
Beijerinckia indica
NCBI taxonomy Id: 395963
Other names: B. indica subsp. indica ATCC 9039, Beijerinckia indica subsp. indica ATCC 9039, Beijerinckia indica subsp. indica str. ATCC 9039, Beijerinckia indica subsp. indica strain ATCC 9039
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