| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Bind_2929 | Bind_2932 | Bind_2929 | Bind_2932 | TIGRFAM: signal peptide peptidase SppA, 36K type; PFAM: peptidase S49; KEGG: azc:AZC_3717 peptidase S49 protein. | PFAM: Peptidase M23; KEGG: bja:blr0433 hypothetical protein. | 0.428 |
| Bind_2929 | rppH | Bind_2929 | Bind_2930 | TIGRFAM: signal peptide peptidase SppA, 36K type; PFAM: peptidase S49; KEGG: azc:AZC_3717 peptidase S49 protein. | NUDIX hydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.513 |
| Bind_2931 | Bind_2932 | Bind_2931 | Bind_2932 | KEGG: mex:Mext_2287 carboxyl-terminal protease; TIGRFAM: carboxyl-terminal protease; PFAM: PDZ/DHR/GLGF domain protein; peptidase S41; Belongs to the peptidase S41A family. | PFAM: Peptidase M23; KEGG: bja:blr0433 hypothetical protein. | 0.935 |
| Bind_2931 | rlmH | Bind_2931 | Bind_2933 | KEGG: mex:Mext_2287 carboxyl-terminal protease; TIGRFAM: carboxyl-terminal protease; PFAM: PDZ/DHR/GLGF domain protein; peptidase S41; Belongs to the peptidase S41A family. | Protein of unknown function DUF163; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. | 0.681 |
| Bind_2931 | rppH | Bind_2931 | Bind_2930 | KEGG: mex:Mext_2287 carboxyl-terminal protease; TIGRFAM: carboxyl-terminal protease; PFAM: PDZ/DHR/GLGF domain protein; peptidase S41; Belongs to the peptidase S41A family. | NUDIX hydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.617 |
| Bind_2932 | Bind_2929 | Bind_2932 | Bind_2929 | PFAM: Peptidase M23; KEGG: bja:blr0433 hypothetical protein. | TIGRFAM: signal peptide peptidase SppA, 36K type; PFAM: peptidase S49; KEGG: azc:AZC_3717 peptidase S49 protein. | 0.428 |
| Bind_2932 | Bind_2931 | Bind_2932 | Bind_2931 | PFAM: Peptidase M23; KEGG: bja:blr0433 hypothetical protein. | KEGG: mex:Mext_2287 carboxyl-terminal protease; TIGRFAM: carboxyl-terminal protease; PFAM: PDZ/DHR/GLGF domain protein; peptidase S41; Belongs to the peptidase S41A family. | 0.935 |
| Bind_2932 | rlmH | Bind_2932 | Bind_2933 | PFAM: Peptidase M23; KEGG: bja:blr0433 hypothetical protein. | Protein of unknown function DUF163; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. | 0.638 |
| Bind_2932 | rppH | Bind_2932 | Bind_2930 | PFAM: Peptidase M23; KEGG: bja:blr0433 hypothetical protein. | NUDIX hydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.603 |
| dapF | rppH | Bind_3404 | Bind_2930 | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | NUDIX hydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.852 |
| hfq | rnr | Bind_1525 | Bind_3416 | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.624 |
| hfq | rppH | Bind_1525 | Bind_2930 | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | NUDIX hydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.552 |
| mraZ | rppH | Bind_0683 | Bind_2930 | PFAM: protein of unknown function UPF0040; KEGG: azc:AZC_4547 MraZ protein; Belongs to the MraZ family. | NUDIX hydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.515 |
| nnrE | rnr | Bind_2191 | Bind_3416 | Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.425 |
| nnrE | rppH | Bind_2191 | Bind_2930 | Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] | NUDIX hydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.801 |
| rlmH | Bind_2931 | Bind_2933 | Bind_2931 | Protein of unknown function DUF163; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. | KEGG: mex:Mext_2287 carboxyl-terminal protease; TIGRFAM: carboxyl-terminal protease; PFAM: PDZ/DHR/GLGF domain protein; peptidase S41; Belongs to the peptidase S41A family. | 0.681 |
| rlmH | Bind_2932 | Bind_2933 | Bind_2932 | Protein of unknown function DUF163; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. | PFAM: Peptidase M23; KEGG: bja:blr0433 hypothetical protein. | 0.638 |
| rlmH | rppH | Bind_2933 | Bind_2930 | Protein of unknown function DUF163; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. | NUDIX hydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.484 |
| rnr | hfq | Bind_3416 | Bind_1525 | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.624 |
| rnr | nnrE | Bind_3416 | Bind_2191 | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] | 0.425 |