| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Bind_3031 | Bind_3294 | Bind_3031 | Bind_3294 | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: xau:Xaut_0477 glutamate synthase (ferredoxin). | PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: fre:Franean1_7058 shikimate dehydrogenase substrate binding domain protein. | 0.532 |
| Bind_3031 | Bind_3295 | Bind_3031 | Bind_3295 | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: xau:Xaut_0477 glutamate synthase (ferredoxin). | PFAM: ROK family protein; KEGG: sil:SPO0860 xylose repressor, putative. | 0.413 |
| Bind_3031 | aroA | Bind_3031 | Bind_1630 | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: xau:Xaut_0477 glutamate synthase (ferredoxin). | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.635 |
| Bind_3031 | aroB | Bind_3031 | Bind_0354 | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: xau:Xaut_0477 glutamate synthase (ferredoxin). | Shikimate kinase., 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.618 |
| Bind_3031 | aroC | Bind_3031 | Bind_1868 | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: xau:Xaut_0477 glutamate synthase (ferredoxin). | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.407 |
| Bind_3031 | aroE-2 | Bind_3031 | Bind_3572 | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: xau:Xaut_0477 glutamate synthase (ferredoxin). | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.532 |
| Bind_3294 | Bind_3031 | Bind_3294 | Bind_3031 | PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: fre:Franean1_7058 shikimate dehydrogenase substrate binding domain protein. | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: xau:Xaut_0477 glutamate synthase (ferredoxin). | 0.532 |
| Bind_3294 | Bind_3295 | Bind_3294 | Bind_3295 | PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: fre:Franean1_7058 shikimate dehydrogenase substrate binding domain protein. | PFAM: ROK family protein; KEGG: sil:SPO0860 xylose repressor, putative. | 0.639 |
| Bind_3294 | aroA | Bind_3294 | Bind_1630 | PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: fre:Franean1_7058 shikimate dehydrogenase substrate binding domain protein. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.698 |
| Bind_3294 | aroB | Bind_3294 | Bind_0354 | PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: fre:Franean1_7058 shikimate dehydrogenase substrate binding domain protein. | Shikimate kinase., 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.975 |
| Bind_3294 | aroC | Bind_3294 | Bind_1868 | PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: fre:Franean1_7058 shikimate dehydrogenase substrate binding domain protein. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.647 |
| Bind_3294 | aroD | Bind_3294 | Bind_2125 | PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: fre:Franean1_7058 shikimate dehydrogenase substrate binding domain protein. | 3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. | 0.937 |
| Bind_3294 | aroE-2 | Bind_3294 | Bind_3572 | PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: fre:Franean1_7058 shikimate dehydrogenase substrate binding domain protein. | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.925 |
| Bind_3294 | glk | Bind_3294 | Bind_3293 | PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: fre:Franean1_7058 shikimate dehydrogenase substrate binding domain protein. | Glucokinase; KEGG: xau:Xaut_4319 glucokinase; TIGRFAM: glucokinase; PFAM: Glucokinase; Belongs to the bacterial glucokinase family. | 0.484 |
| Bind_3294 | ispDF | Bind_3294 | Bind_1516 | PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: fre:Franean1_7058 shikimate dehydrogenase substrate binding domain protein. | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). | 0.499 |
| Bind_3294 | nadD | Bind_3294 | Bind_0412 | PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: fre:Franean1_7058 shikimate dehydrogenase substrate binding domain protein. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.544 |
| Bind_3295 | Bind_3031 | Bind_3295 | Bind_3031 | PFAM: ROK family protein; KEGG: sil:SPO0860 xylose repressor, putative. | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: xau:Xaut_0477 glutamate synthase (ferredoxin). | 0.413 |
| Bind_3295 | Bind_3294 | Bind_3295 | Bind_3294 | PFAM: ROK family protein; KEGG: sil:SPO0860 xylose repressor, putative. | PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: fre:Franean1_7058 shikimate dehydrogenase substrate binding domain protein. | 0.639 |
| Bind_3295 | glk | Bind_3295 | Bind_3293 | PFAM: ROK family protein; KEGG: sil:SPO0860 xylose repressor, putative. | Glucokinase; KEGG: xau:Xaut_4319 glucokinase; TIGRFAM: glucokinase; PFAM: Glucokinase; Belongs to the bacterial glucokinase family. | 0.470 |
| aroA | Bind_3031 | Bind_1630 | Bind_3031 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: xau:Xaut_0477 glutamate synthase (ferredoxin). | 0.635 |