Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Msil_0218KEGG: bra:BRADO6873 two-component sensor histidine kinase; TIGRFAM: PAS sensor protein; PFAM: HWE histidine kinase; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein. (867 aa)    
Predicted Functional Partners:
Msil_2474
Histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: rle:pRL120719 two-component histidine kinase/response regulator motif-containing protein.
 
 
 0.942
Msil_2473
GAF sensor hybrid histidine kinase; PFAM: response regulator receiver; GAF domain protein; ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: met:M446_5171 GAF sensor hybrid histidine kinase.
 
 
 0.931
Msil_3208
Multi-sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; CHASE3 domain protein; KEGG: swi:Swit_4726 multi-sensor hybrid histidine kinase.
 
 
 0.836
Msil_0286
PFAM: response regulator receiver; KEGG: bid:Bind_3239 response regulator receiver protein.
 
 
 0.831
Msil_2780
Histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: pfo:PflO1_2652 histidine kinase.
 
 
 0.818
Msil_3591
KEGG: mes:Meso_1904 PAS/PAC sensor hybrid histidine kinase; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein.
 
 
0.801
Msil_2323
PFAM: response regulator receiver; KEGG: bid:Bind_1267 response regulator receiver and SARP domain protein.
 
 
 0.798
Msil_2700
Diguanylate cyclase/phosphodiesterase with GAF sensor; TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; EAL domain protein; GAF domain protein; KEGG: rpc:RPC_1464 diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains).
 
 
 0.773
Msil_1063
Signal transduction histidine kinase; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; histidine kinase dimerisation/phosphoacceptor; PAS fold-4 domain protein; KEGG: mlo:mlr1749 sensory transduction regulatory protein.
 
  
 0.732
Msil_2699
KEGG: bac:BamMC406_3901 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); TIGRFAM: PAS sensor protein; diguanylate cyclase; PFAM: GGDEF domain containing protein; EAL domain protein; GAF domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein.
  
 
 0.697
Your Current Organism:
Methylocella silvestris
NCBI taxonomy Id: 395965
Other names: M. silvestris BL2, Methylocella silvestris BL2, Methylocella silvestris str. BL2, Methylocella silvestris strain BL2, Methylocella sp. BL2
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