Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Msil_0436TIGRFAM: cytochrome c-type biogenesis protein CcmI; KEGG: bid:Bind_2230 cytochrome c-type biogenesis protein CcmI. (372 aa)    
Predicted Functional Partners:
Msil_0438
PFAM: cytochrome c assembly protein; KEGG: bid:Bind_2232 cytochrome c-type biogenesis protein CcmF.
 
 
 0.970
Msil_0439
Cytochrome C biogenesis protein; Possible subunit of a heme lyase.
 
  
 0.961
ccmE
CcmE/CycJ protein; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family.
 
  
 0.936
Msil_3503
TIGRFAM: periplasmic protein thiol/disulphide oxidoreductase DsbE; PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein; KEGG: bid:Bind_0709 periplasmic protein thiol--disulphide oxidoreductase DsbE.
 
  
 0.818
Msil_0435
PFAM: ATP-binding region ATPase domain protein; KEGG: bid:Bind_2229 integral membrane sensor signal transduction histidine kinase.
 
     0.758
Msil_3507
Heme exporter protein CcmB; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family.
 
   
 0.755
ccmC
Heme exporter protein CcmC; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family.
 
  
 0.628
Msil_0434
Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: rpt:Rpal_2126 two component transcriptional regulator, winged helix family.
       0.620
ccmA
Heme exporter protein CcmA; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
 
   
 0.587
Msil_0433
KEGG: bid:Bind_2227 hypothetical protein.
       0.558
Your Current Organism:
Methylocella silvestris
NCBI taxonomy Id: 395965
Other names: M. silvestris BL2, Methylocella silvestris BL2, Methylocella silvestris str. BL2, Methylocella silvestris strain BL2, Methylocella sp. BL2
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