Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Msil_0528KEGG: bid:Bind_1518 signal transduction histidine kinase, nitrogen specific, NtrB; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein. (381 aa)    
Predicted Functional Partners:
ntrC
Nitrogen metabolism transcriptional regulator, NtrC, Fis Family; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.
 0.994
Msil_0428
PFAM: nitrogen regulatory protein P-II; KEGG: mes:Meso_1545 nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
  
 0.970
Msil_3854
PFAM: nitrogen regulatory protein P-II; KEGG: hch:HCH_06398 nitrogen regulatory protein PII; Belongs to the P(II) protein family.
  
 0.970
Msil_0527
TIM-barrel protein, nifR3 family; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family.
 
  
 0.908
Msil_3527
KEGG: bid:Bind_1983 multi-sensor hybrid histidine kinase; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; SMART: PAS domain containing protein.
 
 
0.873
Msil_0531
Two component, sigma54 specific, transcriptional regulator, Fis family; PFAM: response regulator receiver; sigma-54 factor interaction domain-containing protein; helix-turn-helix Fis-type; SMART: AAA ATPase; KEGG: bid:Bind_1521 two component, sigma54 specific, transcriptional regulator, fis family.
 
 
 0.772
Msil_1861
PFAM: nitrogen regulatory protein P-II; KEGG: bid:Bind_2733 nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
  
 
 0.718
Msil_0159
RNA polymerase, sigma 54 subunit, RpoN; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
   
 0.673
ispDF
2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
       0.672
Msil_2578
Two component, sigma54 specific, transcriptional regulator, Fis family; PFAM: response regulator receiver; sigma-54 factor interaction domain-containing protein; helix-turn-helix Fis-type; KEGG: bid:Bind_0142 two component, sigma54 specific, transcriptional regulator, fis family.
 
 
 0.659
Your Current Organism:
Methylocella silvestris
NCBI taxonomy Id: 395965
Other names: M. silvestris BL2, Methylocella silvestris BL2, Methylocella silvestris str. BL2, Methylocella silvestris strain BL2, Methylocella sp. BL2
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