Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Msil_0883PFAM: acylphosphatase; KEGG: rci:RCIX552 acylphosphatase. (147 aa)    
Predicted Functional Partners:
ackA
Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
     
 0.909
ackA-2
Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
     
 0.909
Msil_2705
PFAM: phosphate acetyl/butaryl transferase; KEGG: cti:RALTA_A1396 putative phosphate acetyl/butyryltransferase.
    
 0.907
acsA
acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
     
 0.902
Msil_2187
PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: rme:Rmet_1899 pyruvate dehydrogenase (cytochrome); Belongs to the TPP enzyme family.
     
 0.902
Msil_2342
PFAM: Aldehyde Dehydrogenase; KEGG: bid:Bind_2852 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.
     
 0.902
Msil_2816
PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mpo:Mpop_1677 thiamine pyrophosphate protein TPP binding domain protein; Belongs to the TPP enzyme family.
     
 0.902
Msil_0085
PFAM: acylphosphatase; KEGG: rpb:RPB_2369 acylphosphatase.
     
  0.900
Msil_1992
PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; KEGG: azc:AZC_0072 putative amidohydrolase.
     
  0.900
Msil_3000
KEGG: cak:Caul_5056 succinate CoA transferase; TIGRFAM: succinate CoA transferase; PFAM: acetyl-CoA hydrolase/transferase.
     
 0.900
Your Current Organism:
Methylocella silvestris
NCBI taxonomy Id: 395965
Other names: M. silvestris BL2, Methylocella silvestris BL2, Methylocella silvestris str. BL2, Methylocella silvestris strain BL2, Methylocella sp. BL2
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