Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ku-2Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (271 aa)    
Predicted Functional Partners:
Msil_1736
TIGRFAM: DNA ligase D; DNA ligase D, 3'-phosphoesterase domain protein; DNA polymerase LigD, polymerase domain protein; DNA polymerase LigD, ligase domain protein; PFAM: DNA primase small subunit; ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: xau:Xaut_4365 ATP-dependent DNA ligase.
 
  
 0.987
ku
Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
  
  
 
0.911
Msil_3103
TIGRFAM: DNA polymerase LigD, ligase domain protein; PFAM: ATP dependent DNA ligase; KEGG: smd:Smed_1305 DNA polymerase LigD ligase region.
 
  
 0.840
Msil_3719
PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: sme:SMb20008 ATP-dependent DNA ligase.
 
  
 0.823
Msil_1732
KEGG: nha:Nham_3998 putative DNA topoisomerase I.
 
    0.584
Msil_1684
PFAM: protein of unknown function DUF72; KEGG: cti:RALTA_A0022 conserved hypothetical protein, DUF72; putative exported protein.
 
    0.550
Msil_1737
PFAM: amine oxidase; KEGG: bid:Bind_3575 amine oxidase.
       0.546
Msil_0289
PFAM: protein of unknown function DUF892; KEGG: rpe:RPE_1822 protein of unknown function DUF892.
 
    0.500
Msil_1738
KEGG: bid:Bind_3574 ferredoxin, 2Fe-2S (AaFd4).
       0.500
Your Current Organism:
Methylocella silvestris
NCBI taxonomy Id: 395965
Other names: M. silvestris BL2, Methylocella silvestris BL2, Methylocella silvestris str. BL2, Methylocella silvestris strain BL2, Methylocella sp. BL2
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